Papers

61,005 results
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Article Tier 2

Individual and combined multigenerational effects induced by polystyrene nanoplastic and glyphosate in Daphnia magna (Strauss, 1820)

Researchers investigated the individual and combined effects of polystyrene nanoplastics and the herbicide glyphosate on the freshwater crustacean Daphnia magna across multiple generations. They found synergistic toxicity when the two contaminants were combined, increasing immobility and reactive oxygen species production. Notably, parental exposure to the mixture caused reproductive effects that persisted into subsequent generations even without continued exposure.

2021 The Science of The Total Environment 64 citations
Article Tier 2

First insight of the intergenerational effects of tri-n-butyl phosphate and polystyrene microplastics to Daphnia magna

Researchers studied the combined effects of polystyrene microplastics and the flame retardant tributyl phosphate on water fleas across multiple generations. They found that co-exposure caused more severe impacts on survival, growth, and reproduction than either contaminant alone, with effects persisting into subsequent generations. The study suggests that microplastics carrying adsorbed chemicals may pose compounding risks to aquatic organisms over time.

2024 The Science of The Total Environment 7 citations
Article Tier 2

Primary and Secondary Plastic Particles Exhibit Limited Acute Toxicity but Chronic Effects on Daphnia magna

Researchers investigated the chronic effects of both primary nanoplastics (polystyrene nanospheres) and secondary micro- and nanoplastics from weathered single-use plastics on Daphnia magna across multiple generations. The study found that nanoplastics accumulated in the intestine and brood chamber, transferred to offspring, and reduced reproduction and physiological function, with effects persisting across generations even after exposure ended.

2020 Environmental Science & Technology 147 citations
Article Tier 2

Combined exposure of polystyrene microplastics and carbamazepine induced transgenerational effects on the reproduction of Daphnia magna

Researchers found that combined exposure to polystyrene microplastics and carbamazepine caused enhanced transgenerational reproductive toxicity in Daphnia magna across two generations, with mixture effects significantly worse than individual exposures.

2023 Environmental Science and Pollution Research 14 citations
Article Tier 2

Adverse multigeneration combined impacts of micro(nano)plastics and emerging pollutants in the aquatic environment

This review examines how micro and nanoplastics combined with other pollutants can cause harm not just to exposed organisms but also to their offspring across multiple generations. The transgenerational effects include changes in growth, reproduction, and gene expression that persist even without continued exposure. This suggests that microplastic pollution could have long-lasting impacts on wildlife populations beyond what single-generation studies reveal.

2023 The Science of The Total Environment 35 citations
Article Tier 2

Polystyrene microplastics facilitating reproductive toxicity and transgenerational transfer of ZnO nanoparticles in daphnia under chronic dietary exposure

Researchers found that polystyrene microplastics facilitated the transfer of zinc oxide nanoparticles across multiple generations of water fleas by impairing their ability to excrete zinc through molting. The microplastics extended the reproductive toxicity of zinc oxide nanoparticles by an additional generation compared to zinc oxide alone. The study suggests that microplastics can act as carriers for other pollutants, amplifying their ecological harm across generations.

2026 Ecotoxicology and Environmental Safety
Article Tier 2

Transgenerational effects and recovery of microplastics exposure in model populations of the freshwater cladoceran Daphnia magna Straus

Researchers tracked the effects of microplastic exposure across four generations of Daphnia magna and found that reproductive impairment and growth reductions persisted into offspring generations that were never directly exposed. The study suggests that microplastics can cause transgenerational effects in freshwater organisms, though partial recovery was observed when exposure ceased.

2018 The Science of The Total Environment 228 citations
Article Tier 2

Combined Effect of Polystyrene Particles and Copper Ions on the Vital Parameters of Daphnia Magna in a Series of Generations

Researchers studied the combined effects of polystyrene microplastics and copper ions on Daphnia magna over four generations using both short-term and continuous exposure designs. Toxicity was greater under combined exposure and increased across generations, suggesting cumulative intergenerational harm from mixed pollutant stress.

2025 Transactions of Papanin Institute for Biology of Inland Waters RAS
Article Tier 2

Polystyrene nanoplastics induced transgenerational reproductive toxicity in Caenorhabditis elegans through enhanced DNA damage accompanied by DNA repair inhibition

Researchers exposed roundworms (C. elegans) to polystyrene nanoplastics at environmentally relevant concentrations and found that reproductive harm persisted across multiple generations, even after exposure stopped. The nanoplastics caused DNA damage while simultaneously suppressing the organisms' DNA repair mechanisms, creating a compounding effect. The study suggests that nanoplastic exposure may have lasting consequences that are passed down through generations, amplifying harm beyond the originally exposed organisms.

2025 Ecotoxicology and Environmental Safety 3 citations
Article Tier 2

Transgenerational impacts of micro(nano)plastics in the aquatic and terrestrial environment

This review summarizes research on the transgenerational impacts of micro- and nanoplastics, showing that exposure can harm not only the directly exposed organisms but also their unexposed offspring. Researchers found that the most commonly reported effects across generations include tissue bioaccumulation, impaired growth and reproduction, oxidative stress, and genetic damage. The study highlights that particle characteristics such as size, polymer type, and degree of aging significantly influence the severity of these transgenerational effects.

2022 Journal of Hazardous Materials 77 citations
Article Tier 2

Tissue translocation, multigenerational and population effects of microplastics in Daphnia magna

This study examined how microplastics are taken up by the water flea Daphnia magna and whether exposure causes multigenerational effects, finding that microplastics can accumulate in body tissues and pass to offspring. The results suggest microplastic pollution poses risks not just to exposed individuals but can affect population health across generations.

2021
Article Tier 2

Polystyrene nanoparticles enhance the adverse effects of di-(2-ethylhexyl) phthalate on male reproductive system in mice

Researchers investigated the combined reproductive toxicity of polystyrene nanoparticles and the plasticizer DEHP in male mice over 35 days. The study found that co-exposure to nanoparticles and DEHP produced enhanced adverse effects on sperm quality and testicular tissue compared to either substance alone, suggesting nanoplastics may amplify the endocrine-disrupting effects of plasticizers.

2022 Ecotoxicology and Environmental Safety 43 citations
Article Tier 2

Multigenerational effects of nanoplastics on life-history traits and physiological responses in Drosophila melanogaster

Researchers conducted a multigenerational study exposing soil springtails (Folsomia candida) to polystyrene nanoplastics across two generations and assessed effects on life-history traits and physiology. Chronic multigenerational NP exposure reduced reproduction and survival, with effects persisting and sometimes intensifying in the second generation.

2025 NanoImpact
Article Tier 2

Transgenerational epigenetic inheritance in Daphnia magna exposed to polyethylene microplastic fragments containing benzophenone-3 additive

Researchers exposed Daphnia magna to polyethylene microplastics containing benzophenone-3 for a single generation and then tracked effects through three subsequent unexposed generations. The study found persistent epigenetic changes across all four generations, including six genes that remained altered throughout, affecting pathways related to detoxification, development, and cardiovascular function, challenging current assumptions about how environmental risk from microplastics should be assessed.

2026 Aquatic Toxicology
Article Tier 2

New Insights into Nanoplastics Ecotoxicology: Effects of Long-Term Polystyrene Nanoparticles Exposure on Folsomia candida

A multigenerational study exposed the soil springtail Folsomia candida to polystyrene nanoplastics for up to three generations, finding that long-term exposure produced reproductive impairment that worsened in F2 and F3 generations, indicating transgenerational ecotoxicological effects.

2023 Toxics 5 citations
Article Tier 2

Parental transfer of nanopolystyrene-enhanced tris(1,3-dichloro-2-propyl) phosphate induces transgenerational thyroid disruption in zebrafish

Researchers investigated the transgenerational effects of nanoplastics combined with the flame retardant TDCIPP on zebrafish thyroid function. The study found that nanopolystyrene enhanced the bioavailability and toxicity of TDCIPP, and that parental exposure induced thyroid disruption that was passed to offspring, suggesting that nanoplastics may amplify the harmful effects of co-occurring pollutants across generations.

2021 Aquatic Toxicology 60 citations
Article Tier 2

Reproductive toxicity of polystyrene nanoplastics in Drosophila melanogaster under multi-generational exposure

Researchers exposed fruit flies to polystyrene nanoplastics across five consecutive generations and found increasing reproductive harm over time, including reduced egg laying and offspring survival. The damage worsened with each generation even at the same exposure levels, suggesting cumulative effects. The study indicates that nanoplastic exposure may pose growing reproductive risks across generations of organisms.

2023 Chemosphere 43 citations
Article Tier 2

The multigenerational effects of nanoplastic exposure on fitness and oxidative stress of Drosophila melanogaster

Researchers assessed the multigenerational effects of nanoplastic exposure on the fitness and oxidative stress levels of a small aquatic crustacean across several generations. Negative effects on reproduction and oxidative balance accumulated across generations, suggesting that multigenerational exposure amplifies the harm from nanoplastics.

2024 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Intergenerational transfer of micro(nano)plastics in different organisms.

This review summarized research on intergenerational transfer of micro(nano)plastics across plants, aquatic animals, and mammals, examining the patterns, pathways, and mechanisms by which MNPs pass from parents to offspring. Transgenerational transfer was documented across diverse species, raising concerns about accumulated multigenerational health burdens.

2025 Journal of hazardous materials
Article Tier 2

Combined exposure of polystyrene microplastics and carbamazepine induced transgenerational effects on the reproduction of Daphnia magna

Researchers found that combined exposure to polystyrene microplastics and the pharmaceutical carbamazepine caused transgenerational reproductive toxicity in water fleas, with the second generation showing significantly reduced offspring numbers and disrupted expression of reproduction-related genes.

2023 Research Square (Research Square) 2 citations
Article Tier 2

Parental exposure to nanoplastics and offspring sensitivity to environmental contamination: A case study with polystyrene

Researchers exposed polychaete worms (Hediste diversicolor) to 100 nm polystyrene nanoplastics for 28 days, induced reproduction, raised offspring for six months, then challenged those offspring with arsenic at 0 and 50 and 250 µg/L to test whether parental nanoplastic exposure altered offspring sensitivity to a co-contaminant. Offspring of nanoplastic-exposed parents showed elevated antioxidant enzyme activity, including superoxide dismutase and glutathione S-transferase, suggesting parental exposure can modulate the toxicological response of subsequent generations.

2022 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Di-(2-ethylhexyl) phthalate exacerbated the toxicity of polystyrene nanoplastics through histological damage and intestinal microbiota dysbiosis in freshwater Micropterus salmoides

Researchers studied the combined effects of polystyrene nanoplastics and the plasticizer DEHP on juvenile largemouth bass through dietary and waterborne exposure. They found that DEHP worsened the toxic effects of nanoplastics, causing greater tissue damage in the liver and intestines and significant disruption of the gut microbiome. The study suggests that nanoplastics carrying adsorbed chemical pollutants may pose amplified risks to freshwater fish health.

2022 Water Research 60 citations
Article Tier 2

The multigenerational effects of nanoplastic exposure on fitness and oxidative stress of Drosophila melanogaster

Researchers tracked the effects of nanoplastic exposure on fitness and oxidative stress markers across multiple generations of a small aquatic invertebrate. Reproductive success and antioxidant defenses deteriorated progressively across generations, suggesting that multigenerational exposure to nanoplastics causes cumulative ecological harm.

2024 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Effects of nanoplastics at predicted environmental concentration on Daphnia pulex after exposure through multiple generations

Researchers exposed water fleas (Daphnia pulex) to environmentally realistic nanoplastic concentrations across three generations over 63 days. They found that while the first two generations showed mainly molecular-level stress responses, the third generation experienced reduced growth and reproduction along with suppressed antioxidant defenses. The study suggests that even very low nanoplastic concentrations can have significant long-term toxic effects that worsen across generations and may take multiple generations to recover from.

2019 Environmental Pollution 177 citations