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61,005 resultsShowing papers similar to Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites
ClearMicroplastic particles in human blood and their association with coagulation markers
In a study of 36 healthy adults, microplastics were detected in the blood of 89% of participants, with polypropylene and polyethylene being the most common types found. Higher microplastic levels were associated with changes in blood clotting markers, suggesting that plastic particles in our bloodstream may affect how our blood coagulates, though larger studies are needed to confirm this link.
Microplastic Effects on Thrombin–Fibrinogen Clotting Dynamics Measured via Turbidity and Thromboelastography
Researchers found that microplastics directly altered fibrin clot formation dynamics in a human thrombin-fibrinogen model, with effects varying by plastic type, size, and concentration, suggesting potential impacts on blood clotting and cardiovascular health.
Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence
This study provides the first direct photographic and chemical evidence of microplastics and pigment microparticles inside human blood clots (thrombi). A large number of non-soluble synthetic particles were found accumulated in arterial tissue, suggesting that the health risks of microparticle exposure have been underestimated. The findings raise serious questions about whether microplastics circulating in the bloodstream could contribute to blood clot formation and cardiovascular events.
Circulating Microplastics as Acute Triggers of Platelet Activation and Coagulation: Implications for Cardiovascular Risk
Researchers exposed human platelets to nanoplastics and found direct activation of platelet aggregation and coagulation pathways at environmentally relevant concentrations. The results suggest that circulating microplastics and nanoplastics could act as acute triggers of thrombosis, with implications for cardiovascular disease risk.
Evidence, Mechanisms, and Clinical Implications of Microplastics and Nanoplastics As Emerging Cardiovascular Risk Factors: A Narrative Review
This review examines growing evidence that micro- and nanoplastics may contribute to cardiovascular health risks, with researchers having found these particles in human artery plaques and blood clots. Evidence indicates that the particles can enter the bloodstream, trigger inflammation, damage blood vessel walls, and potentially increase the risk of heart attacks and strokes. While the evidence is not yet conclusive, the study highlights an emerging area of concern that warrants further investigation into how everyday plastic exposure may affect heart and blood vessel health.
Tissue-specific distribution of microplastics in human blood and carotid plaques: A paired sample analysis
In a study of 20 patients undergoing surgery for clogged neck arteries, researchers found microplastics in both blood and artery plaque samples from every patient. The plaques contained nearly six times more microplastics than blood, suggesting that plastics accumulate in damaged blood vessels. Some types of microplastics were linked to changes in cholesterol levels, raising questions about whether plastic particles could worsen heart disease.
Micro- and nanoplastics are elevated in femoral atherosclerotic plaques compared with undiseased arteries
Researchers found significantly higher concentrations of microplastics and nanoplastics in diseased arterial plaques from human patients with limb-threatening vascular disease compared to healthy arteries, adding to growing evidence that these particles accumulate in cardiovascular tissue and may play a role in artery disease.
Weathered microplastics in human blood: unraveling the effect of structural changes at the particle surface on coagulation and platelet activation
Researchers exposed human whole blood to microplastics that had been artificially aged to simulate real environmental weathering, finding that weathered plastics like polystyrene, PVC, and PET triggered significantly stronger blood clotting and platelet activation than fresh plastic particles. The findings suggest that the longer plastic sits in the environment and degrades, the more dangerous it may become to human cardiovascular health.
Environmental microplastic and nanoplastic: Exposure routes and effects on coagulation and the cardiovascular system
This review explores how environmental microplastic and nanoplastic particles may affect blood coagulation and the cardiovascular system in humans. Researchers summarized evidence suggesting that plastic particles can enter the body through ingestion, inhalation, and skin contact, potentially triggering inflammatory responses in blood vessels. The study highlights the need for more research on how chronic exposure to these tiny plastic particles may contribute to cardiovascular health risks.
Micro and Nano-plastic particles: What are they and do they effect cardiovascular health?
This review examines the cardiovascular health effects of micro- and nanoplastics, summarizing evidence that these particles have been detected in human tissues including arterial plaques and may promote endothelial dysfunction and inflammation. The authors call for further clinical and epidemiological research into cardiac risk.
Microplastics in the Lung Tissues Associated with Blood Test Index
Researchers analyzed lung tissue from 12 nonsmoking patients and found microplastics in all samples, with 12 different plastic types detected and polypropylene being the most common. Women and people living near major roads had higher microplastic levels in their lungs, and the amounts correlated with changes in blood clotting markers. This study provides direct evidence that microplastics accumulate in human lungs and may affect blood health, even in people who have never smoked.
Microplastic contamination of donated blood and red cell concentrates
Researchers investigated whether blood donation and processing procedures introduce microplastics into transfusion products, finding that plastic blood collection packs and processing steps may contribute to microplastic contamination. Microplastics have previously been found in human blood at varying concentrations, with potential associations to vascular and thrombotic effects. The study raises important questions about whether blood processing equipment may be an underrecognized source of microplastic exposure for transfusion recipients.
PB1065 Microvesicles Display Opposite Coagulolytic Balances According to Their Cellular Origin and Activation Status
Polystyrene microplastics activated human vascular endothelial cells, upregulating inflammation markers ICAM-1 and VCAM-1, and promoted larger and denser blood clot formation when added to whole blood perfused over collagen at concentrations found in human plasma. These results raise concern that microplastics circulating in human blood could increase the risk of thrombosis and cardiovascular events.
Microfluidic-based in vitro thrombosis model for studying microplastics toxicity
Researchers developed a microfluidic-based thrombosis model to study how microplastics interact with the vascular system. Using both a mouse model and an on-chip system, the study found that microplastic exposure led to accumulation in the blood and decreased binding of fibrin to platelets, suggesting a potential risk of thrombus instability in blood flow.
Analytical techniques for detecting micro- and nanoplastics in blood and vascular tissues: Strengths and limitations
Researchers reviewed analytical techniques for detecting micro- and nanoplastics in blood and vascular tissues, assessing each method's strengths and limitations. The study highlights that human-derived samples pose unique challenges due to limited volumes, high lipid and protein content, and contamination risks, emphasizing the need for standardized protocols to produce reliable data for cardiovascular health research.
Microplastics, Nanoplastics and Heart Contamination: The Hidden Threat
This review examines growing evidence that micro- and nanoplastics can accumulate in human cardiovascular tissues, including blood, heart muscle, and arterial plaques. Researchers found that these particles may contribute to heart and blood vessel problems through inflammation, oxidative stress, blood clotting, and direct tissue injury. The study identifies plastic particles as a potential new environmental risk factor for cardiovascular health.
Microplastics and Nanoplastics in Atheromas and Cardiovascular Events
This landmark clinical study found that patients with micro- and nanoplastics detected in their carotid artery plaque had a significantly higher risk of heart attack, stroke, or death over a 34-month follow-up period compared to those without detectable plastics. This is one of the first studies to directly link microplastic presence in human blood vessels to worse cardiovascular outcomes. The findings suggest that plastic accumulation in arteries may be an important and previously unrecognized risk factor for heart disease.
Quantitation of micro and nanoplastics in human blood by pyrolysis-gas chromatography–mass spectrometry
Researchers developed and validated an improved method using pyrolysis-gas chromatography to measure specific plastic polymer types in human blood, detecting plastics in 64 out of 68 blood samples tested with a mean concentration of 268 nanograms per milliliter. Polyethylene was the most common polymer found, underscoring that microplastic and nanoplastic particles are already circulating inside the human body.
Standardizing methodologies to study microplastics and nanoplastics in cardiovascular diseases
Researchers highlighted that microplastics and nanoplastics are emerging as new risk factors for cardiovascular health, with evidence indicating they can impair blood vessel cell functions and worsen artery-clogging processes. However, the widely varying concentrations of these particles found in heart and vascular tissues point to a lack of standardized research methods. The study calls for unified approaches to better understand how plastic particles affect the cardiovascular system.
Microplastics in three types of human arteries detected by pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS)
Researchers detected microplastics in all 17 human artery samples tested, including coronary arteries, carotid arteries, and the aorta. Arteries with atherosclerotic plaques (hardened, narrowed areas) contained significantly more microplastics than plaque-free arteries. This suggests that microplastic accumulation may be associated with atherosclerosis, the buildup of fatty deposits in arteries that is a leading cause of heart attacks and strokes.
Micro/nano-plastics impacts in cardiovascular systems across species
This review summarizes research across multiple species showing that microplastics and nanoplastics can damage the cardiovascular system, causing blood clots, blood vessel injury, and heart problems in lab animals. Since these tiny particles have been found in human blood and can travel throughout the body, the findings raise serious concerns about the long-term heart health effects of microplastic exposure in people.
Tracing Microplastics in the Human Body: From Detection to Disease Mechanisms
This review traces the detection of microplastics across multiple human tissues — from nasal lavage and bronchoalveolar fluid to blood and lung tissue — and examines the disease mechanisms linking plastic particle accumulation to respiratory, cardiovascular, and other systemic health effects.
The Invisible Threat: Microplastics in Human Blood and Placenta
This review summarized current evidence on microplastic detection in human blood and placenta, discussing what is known about how these particles enter the bloodstream and reach fetal tissue. The authors highlight the potential implications for maternal and fetal health.
Evaluation of Microplastic Content in Human Circulatory System and Its Potential Impacts on Systemic Health
Researchers detected microplastics in blood samples from 76% of 50 healthy adults using FTIR and Raman spectroscopy, with an average concentration of about 3 particles per milliliter. PET and polypropylene were the most common polymer types found, and the study discusses potential systemic health implications of circulating microplastics in the human body.