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61,005 resultsShowing papers similar to Nanoplastic-induced Disruption of DPPC and Palmitic Acid Monolayers: Implications for Membrane Integrity
ClearNanoplastic-induced Disruption of DPPC and Palmitic Acid Films: Implications for Membrane Integrity
Researchers modeled how nanoplastic particles disrupt lipid monolayer films of dipalmitoylphosphatidylcholine (DPPC) and palmitic acid that mimic lung surfactant, finding that nanoplastics caused structural disruption of the surfactant film with implications for respiratory function in exposed individuals.
Nanoplastic-induced Disruption of DPPC and Palmitic Acid Monolayers: Implications for Membrane Integrity
Polystyrene nanoplastics were found to disrupt DPPC and palmitic acid lipid monolayers—models of lung alveolar and cell membranes—suggesting that inhaled or ingested nanoplastics could compromise lung alveolar stability, cell signaling, nutrient delivery, and potentially cause neurotoxicity through membrane disruption.
Nanoplastic-InducedDisruption of DPPC and PalmiticAcid Films: Implications for Membrane Integrity
Researchers investigated how polystyrene nanoplastics disrupt model lung surfactant films composed of DPPC and palmitic acid, finding that nanoplastics intercalate into and destabilize these lipid membranes in ways that could impair respiratory function in people who inhale plastic particles.
Nanoplastic-Induced Disruption of DPPC and Palmitic Acid Films: Implications for Membrane Integrity
Researchers studied how nanoplastics interact with lung and cell membrane lipids at the molecular level. They found that polystyrene nanoplastics can physically insert themselves into lipid films that mimic cell membranes, with greater disruption at higher concentrations. These findings help explain how nanoplastics may penetrate cellular barriers, potentially affecting lung function and allowing the particles to accumulate in biological tissues.
Molecular modeling of nanoplastic transformations in alveolar fluid and impacts on the lung surfactant film
Researchers used molecular dynamics simulations to model how inhaled nanoplastics interact with lung surfactant fluid at the air-water interface in the lungs. They found that lung surfactant molecules spontaneously coat nanoplastics to form coronas, and that some plastic types can be dissolved by lung surfactant, potentially increasing the bioavailability of toxic additives. The study suggests that nanoplastics could disrupt normal lung surfactant function, raising concerns about respiratory health effects.
Understanding the transformations of nanoplastic onto phospholipid bilayers: Mechanism, microscopic interaction and cytotoxicity assessment
Researchers used molecular dynamics simulations to model how five types of nanoplastics (PVC, PS, PLA, PP, PET) interact with cell membrane lipid bilayers, finding that van der Waals forces dominate uptake and that nanoplastic accumulation reduces membrane thickness in a way that correlates with cytotoxicity.
Can Nanoplastics Alter Cell Membranes?
Researchers used molecular dynamics simulations to show that polyethylene nanoplastics dissolve into the hydrophobic core of lipid bilayers as disentangled polymer chains, inducing structural and dynamic changes that alter vital cell membrane functions and may result in cell death.
Insights into short chain polyethylene penetration of phospholipid bilayers via atomistic molecular dynamics simulations
Molecular dynamics simulations revealed that short-chain polyethylene fragments can penetrate phospholipid bilayer membranes, providing atomic-level insight into how nanoscale plastic particles may disrupt cell membrane integrity.
Effects of Nanoplastics on Lipid Membranes and Vice Versa: Insights from All-Atom Molecular Dynamics Simulations
Researchers used molecular dynamics simulations to study how polyethylene nanoplastics interact with cell membrane models. They found that the mechanical properties of the lipid membrane, rather than the nanoplastic structure, primarily determine whether particles can penetrate cells. The study suggests that more flexible biological membranes may be more susceptible to nanoplastic penetration, providing insight into how these particles could enter living cells.
Interaction of polyethylene nanoplastics with the plasma, endoplasmic reticulum, Golgi apparatus, lysosome and endosome membranes: A molecular dynamics study
Researchers used computer simulations to study how polyethylene nanoplastics interact with five types of cell membranes in the human body, finding that the plastic particles spontaneously insert themselves into the fatty inner layer of membranes and disrupt normal membrane flexibility. These atomic-level findings help explain how nanoplastics may cause cell damage from the inside.
Molecular interactions and dynamics of microplastics in indoor dust with lung-inflammatory receptors: A study in academic settings
Researchers used molecular simulation to study how microplastics in indoor dust interact with lung-lining lipid molecules, finding that MP surfaces adsorb lung surfactant components in ways that could impair pulmonary surfactant function and increase inflammatory signaling after inhalation.
Polystyrene-Induced Dehydration of Lipid Membranes: Insights from Atomistic Simulations
Atomistic molecular dynamics simulations revealed that polystyrene nanoplastics cause dehydration of lipid membranes upon contact, extracting water molecules from the bilayer interface in ways that could alter membrane structure and function relevant to cellular uptake of nanoplastic particles.
Nanoplastics Alter Lateral and Transverse Distributions of Cholesterol in Model Cell Membranes
Researchers used atomic-scale molecular dynamics simulations to model how nanoplastics alter the lateral and transverse distribution of cholesterol in model cell membranes. Nanoplastic insertion disrupted lipid bilayer organisation, raising concerns that membrane cholesterol redistribution could impair normal cell signalling and membrane function.
Polystyrene-InducedDehydration of Lipid Membranes:Insights from Atomistic Simulations
Researchers conducted atomistic simulations to examine how polystyrene nanoplastics induce dehydration in lipid bilayer membranes after penetrating the membrane interior. The simulation results provided molecular-level evidence that nanoplastic-membrane interactions cause lipid dehydration, offering mechanistic insight into how nanoplastics may disrupt cellular membrane function.
Polystyrene-InducedDehydration of Lipid Membranes:Insights from Atomistic Simulations
Researchers used atomistic molecular dynamics simulations to investigate the dehydration of lipid membranes caused by polystyrene nanoplastics that have penetrated the bilayer. The findings revealed how nanoplastic particles alter the hydration state of membrane lipids, providing detailed mechanistic understanding of nanoplastic interactions with biological membranes.
Polystyrene-InducedDehydration of Lipid Membranes:Insights from Atomistic Simulations
Researchers performed atomistic molecular dynamics simulations to characterize how polystyrene nanoplastics interact with and dehydrate lipid bilayer membranes following membrane penetration. The simulations revealed the structural and thermodynamic mechanisms by which nanoplastic particles disrupt membrane hydration, contributing to understanding of nanoplastic toxicity at the cellular level.
Polystyrene-InducedDehydration of Lipid Membranes:Insights from Atomistic Simulations
Researchers used atomistic molecular dynamics simulations to investigate how polystyrene nanoplastics interact with lipid bilayer membranes after penetrating them, focusing specifically on whether and how such particles induce membrane dehydration. They found that polystyrene nanoplastics cause significant dehydration of lipid membranes, providing new mechanistic insight into nanoplastic-induced cellular disruption.
Polyvinyl Chloride Nanoparticles Affect Cell Membrane Integrity by Disturbing the Properties of the Multicomponent Lipid Bilayer in Arabidopsis thaliana
Researchers found that polyvinyl chloride nanoparticles disrupt the properties of the multicomponent lipid bilayer in Arabidopsis thaliana cell membranes, compromising membrane integrity and providing molecular-level evidence for how nanoplastics can impair plant cell function.
Pollution caused by nanoplastics: adverse effects and mechanisms of interaction via molecular simulation
This review used molecular simulation techniques to examine how nanoplastics interact with biological membranes and proteins, finding that NPs alter lipid membrane organization and protein secondary structure, potentially disrupting digestion and nutrient absorption in the gastrointestinal system. The review synthesized evidence that NPs can also adsorb environmental contaminants and potentiate their toxicity through synergistic mechanisms.
Distinguishing the nanoplastic–cell membrane interface by polymer type and aging properties: translocation, transformation and perturbation
Molecular simulations revealed that nanoplastic behavior at cell membranes differs significantly by polymer type and aging state, with distinct patterns of membrane translocation, transformation, and disruption. Aged nanoplastics showed altered interaction dynamics compared to pristine particles, suggesting weathering changes ecotoxicological risk.
Nanosized microplastics damage cell membranes by altering lateral and transverse distributions of cholesterol
Researchers used atomic-scale molecular dynamics simulations to investigate how nanosized polystyrene microplastics interact with cholesterol-containing model cell membranes, examining changes to lateral and transverse cholesterol distributions. The simulations reveal that nanoplastic particles disrupt membrane organization by altering cholesterol positioning, providing a molecular mechanism for the membrane damage associated with nanoplastic exposure.
Effect of Silica Microparticles on Interactions in Mono- and Multicomponent Membranes
This study used Langmuir monolayer techniques to examine how silica microparticles interact with phospholipid membranes containing cholesterol, modeling how inhaled pollutant particles interact with lung cell membranes. Silica particles at environmentally relevant concentrations altered membrane surface pressure and compressibility in ways dependent on cholesterol content, with implications for understanding particulate matter toxicity.
Effects of polyethylene microplastics on cell membranes: A combined study of experiments and molecular dynamics simulations
Researchers combined laboratory experiments with molecular dynamics simulations to study how polyethylene microplastics interact with cell membranes. They found that nanoscale plastic particles can penetrate and disrupt cell membrane structure, causing leakage and potentially leading to cell damage. The study provides a detailed molecular-level understanding of one of the fundamental ways microplastics may harm living cells.
Understanding interactions between oligomeric plastic and lung-sufactants underpinning inhalation risks of airborne plastics
Researchers investigated how oligomeric plastic particles interact with lung surfactant bilayers to understand inhalation risks, proposing that as plastics break down to oligomeric sizes through environmental degradation they may penetrate and disrupt the protective surfactant layer lining the lungs.