Papers

61,005 results
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Article Tier 2

Single and combined toxicity effects of microplastics and perfluorooctanoic acid on submerged macrophytes and biofilms

Researchers tested the combined effects of four common microplastic types and PFOA (a forever chemical) on aquatic plants and their associated biofilms. The pollutants together caused more damage to plant growth, photosynthesis, and microbial communities than either pollutant alone. Since microplastics and PFOA frequently co-occur in the environment, their combined toxic effects on aquatic ecosystems could have downstream consequences for water quality and human exposure.

2023 The Science of The Total Environment 33 citations
Article Tier 2

Perfluorooctanoic acid and concomitant microplastics pollution impact nitrogen elimination processes and increase N2O emission in wetlands through regulation of the functional microbiome

This study found that the industrial chemical PFOA, when combined with microplastics, significantly disrupts nitrogen processing in wetlands and increases emissions of the potent greenhouse gas nitrous oxide. Researchers observed that PFOA alone inhibited important nitrogen-removal processes, and the addition of microplastics, especially biodegradable PLA plastic, made the problem worse. The findings suggest that combined pollution from forever chemicals and microplastics may be undermining the natural water-cleaning ability of wetland ecosystems.

2025 Water Research 12 citations
Article Tier 2

The co-presence of polystyrene nanoplastics and ofloxacin demonstrates combined effects on the structure, assembly, and metabolic activities of marine microbial community

Researchers examined the combined effects of polystyrene nanoplastics and the antibiotic ofloxacin on marine microbial communities. They found that the two pollutants together had a greater impact on bacterial community structure and metabolic activity than either one alone. The study suggests that nanoplastics and antibiotics co-occurring in the ocean may work together to disrupt the microorganisms that support marine ecosystem health.

2023 Journal of Hazardous Materials 20 citations
Article Tier 2

Polystyrene microplastics enhanced the effect of PFOA on Chlorella sorokiniana: Perspective from the cellular and molecular levels

This study found that polystyrene microplastics made the toxic effects of PFOA (a "forever chemical") worse on algae by increasing cell membrane permeability, allowing more PFOA to enter the cells. The findings matter because microplastics and PFOA often exist together in the environment, and their combined effect can be more harmful than either pollutant alone.

2024 Journal of Hazardous Materials 61 citations
Article Tier 2

Enhanced uptake of perfluorooctanoic acid by polystyrene nanoparticles in Pacific oyster (Magallana gigas)

Researchers found that polystyrene nanoparticles significantly enhanced the uptake of the toxic chemical PFOA in Pacific oysters. The presence of 20 nm nanoparticles increased PFOA absorption by up to 3.2-fold and amplified PFOA-induced oxidative stress by 3-fold, suggesting that nanoplastics can act as carriers that worsen the effects of other environmental contaminants in marine organisms.

2024 Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 3 citations
Article Tier 2

Interaction and combined toxicity of microplastics and per- and polyfluoroalkyl substances in aquatic environment

This review examines how microplastics interact with per- and polyfluoroalkyl substances (PFAS) in aquatic environments and the combined toxic effects on organisms. Researchers found that microplastics can adsorb PFAS chemicals and transport them through water systems, potentially increasing exposure for aquatic life. The study highlights that the combination of these two widespread pollutant types may pose greater ecological risks than either one alone.

2022 Frontiers of Environmental Science & Engineering 83 citations
Article Tier 2

Polystyrene modulation of perfluorooctanoic acid toxicity in zebrafish: Transcriptomic and toxicological insights

Researchers exposed zebrafish to the industrial chemical PFOA both alone and in combination with polystyrene microplastics of different sizes to understand how the particles influence chemical toxicity. They found that PFOA disrupted neurotransmitter pathways, and the addition of microplastics modified this toxicity in a size-dependent manner, with smaller particles generally increasing harmful effects. The study provides evidence that microplastics can alter how other environmental pollutants affect living organisms.

2025 Journal of Hazardous Materials 3 citations
Article Tier 2

Combined Environmental Impacts and Toxicological Interactions of Per- and Polyfluoroalkyl Substances (PFAS) and Microplastics (MPs)

This review examines how microplastics and per- and polyfluoroalkyl substances (PFAS) frequently co-occur in the environment and interact to alter each other's environmental fate and biological effects. Researchers found that co-exposure can enhance PFAS bioaccumulation by up to 2.5-fold compared to PFAS alone, accompanied by amplified oxidative stress, immune disruption, and reproductive impairment in aquatic organisms. The magnitude and direction of combined effects depend heavily on polymer type, particle size, surface aging, and biological context.

2026 Environments
Article Tier 2

Interactions of microplastics and organic compounds in aquatic environments: A case study of augmented joint toxicity

Researchers investigated how polystyrene microplastics interact with the antimicrobial compound triclosan in simulated environmental and cellular conditions. They found that surface-functionalized microplastics adsorbed significantly more triclosan and released it under cellular conditions, with the combination producing greater toxicity to human intestinal cells than either contaminant alone. The study suggests that microplastics can amplify the harmful effects of co-occurring organic pollutants.

2021 Chemosphere 77 citations
Article Tier 2

The exploration of chronic combined toxic mechanisms of environmental PFOA and polyethylene micro/nanoplastics on adult zebrafish (Danio rerio), using aquatic microcosm systems

Researchers studied the combined toxic effects of polyethylene micro/nanoplastics and the chemical pollutant PFOA on zebrafish in conditions mimicking real aquaculture systems. They found that the combination produced time-dependent toxicity patterns, with effects on the liver, gut, and reproductive systems that were sometimes more severe than either pollutant alone. The study highlights that microplastics and industrial chemicals can interact in ways that amplify their individual harms to aquatic life.

2025 Aquatic Toxicology 4 citations
Article Tier 2

Combined influence of the nanoplastics and polycyclic aromatic hydrocarbons exposure on microbial community in seawater environment

Researchers studied the individual and combined effects of nanoplastics and polycyclic aromatic hydrocarbons on microbial communities in seawater. They found that the combination of these two pollutants altered microbial diversity and community structure differently than either pollutant alone. The study suggests that the interaction between nanoplastics and chemical pollutants in the ocean may have complex and unpredictable effects on marine microbial ecosystems.

2024 The Science of The Total Environment 7 citations
Article Tier 2

Co-exposure to polystyrene microplastics and perfluorooctanoic acid can exacerbate lipid metabolism disorders and liver damage in adult zebrafish

Researchers exposed zebrafish to polystyrene microplastics and the persistent pollutant PFOA separately and together for 28 days, finding that combined exposure caused greater intestinal barrier breakdown, liver damage, lipid metabolism disruption, and gut microbiome dysbiosis than either contaminant alone — raising concerns about nonalcoholic fatty liver disease risk from co-occurring plastic and chemical pollution.

2025 Journal of Environmental Sciences 1 citations
Article Tier 2

Polystyrene microplastics attenuated the impact of perfluorobutanoic acid on Chlorella sorokiniana: Hetero-aggregation, bioavailability, physiology, and transcriptomics

Researchers studied how polystyrene microplastics interact with PFBA (a type of forever chemical) when both are present around green algae. Surprisingly, the microplastics actually reduced the toxic effects of PFBA on the algae by binding to the chemical and making it less available, showing that pollutant interactions in the environment can be more complex than expected.

2025 Journal of Hazardous Materials 14 citations
Article Tier 2

Microplastics as carriers of per- and polyfluoroalkyl substances (PFAS) in aquatic environment: interactions and ecotoxicological effects

Researchers reviewed how microplastics serve as carriers for per- and polyfluoroalkyl substances (PFAS), sometimes called forever chemicals, in aquatic environments. The study found that PFAS can attach to microplastic surfaces and accumulate in organisms through the food chain, potentially amplifying the toxic effects of both pollutants. The findings suggest that the combined presence of microplastics and PFAS poses a greater environmental and health risk than either pollutant alone.

2023 Water Emerging Contaminants & Nanoplastics 49 citations
Article Tier 2

Effects of co-exposure to microplastics and perfluorooctanoic acid on the Caco-2 cells

This study tested what happens when human intestinal cells are exposed to PET microplastics combined with PFOA, a persistent chemical pollutant often called a forever chemical. The combination was more toxic than either substance alone, causing greater cell damage and weakening the intestinal barrier that normally keeps harmful substances out of the bloodstream. The findings suggest that microplastics carrying adsorbed pollutants like PFOA could pose greater risks to gut health than microplastics by themselves.

2025 Toxicology 6 citations
Article Tier 2

Unraveling the complexities of microplastics and PFAS synergy to foster sustainable environmental remediation and ecosystem protection: A critical review with novel insights

This review examines how microplastics and PFAS (sometimes called 'forever chemicals') interact in the environment, since both often come from the same everyday products. The authors found that microplastics can carry PFAS on their surface, and when organisms are exposed to both together, the combined toxic effects including oxidative stress and reproductive harm can be worse than either pollutant alone.

2025 Journal of Hazardous Materials Advances 13 citations
Article Tier 2

Interactions between MPs and PFASs in aquatic environments: A dual-character situation

This review examines the interactions between microplastics and per- and polyfluoroalkyl substances (PFAS) in water environments, finding that the two pollutants have a complex relationship. Microplastics can absorb PFAS chemicals onto their surfaces, potentially transporting them through aquatic systems and altering their environmental behavior. The study highlights the need to consider these combined effects when assessing pollution risks in waterways.

2023 Journal of Environmental Management 26 citations
Article Tier 2

A tale of two emerging contaminants: Interfacial interactions, co-transport behaviors and ecotoxicological implications between per-and polyfluoroalkyl substances and micro(nano)plastics.

This review examined how PFAS and micro/nanoplastics co-occur in the environment, form interfacial adsorption complexes, and interact synergistically within organisms. The authors found that the two contaminant classes amplify each other's toxicity in co-exposure scenarios and that their shared transport pathways complicate standard risk assessment.

2026 Advances in colloid and interface science
Article Tier 2

Effects of combined exposure of PVC and PFOA on the physiology and biochemistry of Microcystis aeruginosa

Researchers examined the combined effects of PVC microplastics and the PFAS chemical PFOA on a common freshwater algae species. They found that the combination inhibited algal growth and promoted the release of microcystin toxins, while also causing physical damage to the cells. The study suggests that the co-presence of microplastics and PFAS in water bodies may create compounding risks for aquatic ecosystems.

2023 Chemosphere 28 citations
Article Tier 2

Microplastics and PFAS as ubiquitous pollutants affect potencies of highly toxic chemicals in mixtures

Researchers investigated how ubiquitous pollutants like PFAS and microplastics affect the toxicity of other highly toxic chemicals when present together in mixtures. They found that even at non-toxic concentrations, PFAS and microplastics could alter the potency of co-occurring toxic compounds. The study highlights the importance of considering pollutant interactions in complex environmental mixtures rather than assessing chemicals in isolation.

2025 Journal of Hazardous Materials 1 citations
Article Tier 2

From co-occurrence to co-existence and co-exposure: Associations between per- and polyfluoroalkyl substances and microplastics in the environment

This review examines the growing recognition that PFAS chemicals and microplastics frequently co-occur in the environment and may interact in ways that affect both ecological and human health. Researchers identified four major sources that emit both pollutants simultaneously and found strong evidence that PFAS can adsorb onto microplastic surfaces and be co-transported through the environment. The study calls for standardized methods and long-term studies to better understand the combined exposure risks of these two widespread contaminant classes.

2025 Journal of Hazardous Materials 2 citations
Article Tier 2

Trophic transfer and interfacial impacts of micro(nano)plastics and per-and polyfluoroalkyl substances in the environment.

This review examined the co-occurrence, trophic transfer, and interactions of micro(nano)plastics and PFAS (per- and polyfluoroalkyl substances) in the environment, highlighting how their combined persistence and toxicity create compounding risks for ecosystems and human health.

2024 Journal of hazardous materials
Article Tier 2

Polystyrene nanoplastics amplify the toxic effects of PFOA on the Chinese mitten crab (Eriocheir sinensis)

Nanoplastics amplified the toxic effects of PFOA (a "forever chemical") in Chinese mitten crabs, worsening oxidative stress, immune disruption, and intestinal inflammation beyond what either pollutant caused alone. The combination disrupted fat metabolism and triggered cell death pathways, demonstrating how two common environmental contaminants can interact to create greater health risks in organisms that humans consume as food.

2025 Journal of Hazardous Materials 19 citations
Article Tier 2

Micro- and nanoplastics effects in a multiple stressed marine environment

Researchers examined how micro- and nanoplastics interact with other environmental stressors in marine settings, finding that realistic multi-stressor scenarios can amplify or modify plastic toxicity in ways single-exposure studies miss.

2022 Journal of Hazardous Materials Advances 21 citations