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Papers
61,005 resultsShowing papers similar to Highlights
ClearMarine, freshwater, and terrestrial snails as models in the biomedical applications
This review highlights the value of marine, freshwater, and terrestrial snails as model organisms in biomedical research, covering their use in pharmacology, toxicology, and as tools for studying the effects of environmental contaminants.
Chestnut Shell Tannins: Effects on Intestinal Inflammation and Dysbiosis in Zebrafish
Researchers tested chestnut shell tannin extract in zebrafish with induced intestinal inflammation and dysbiosis, finding that tannin treatment reduced inflammatory markers and partially restored gut microbiome composition, suggesting potential as a natural anti-inflammatory dietary supplement.
Gut microbiota in parasite-transmitting gastropods
This review summarizes current knowledge about the gut microbiome of gastropod snails, particularly species that transmit parasites to humans and animals. Researchers found that factors including diet, habitat, and parasite infection status all influence the microbial communities living inside these snails. The study suggests that a better understanding of snail gut bacteria could lead to new biological approaches for controlling snail-borne diseases.
Lactobacillus plantarum A3 attenuates ulcerative colitis by modulating gut microbiota and metabolism
Researchers showed that Lactobacillus plantarum A3, a probiotic strain isolated from horses, reduced symptoms of ulcerative colitis in mice whose gut microbiomes had been disrupted by antibiotics. The probiotic restored beneficial bacteria like Akkermansia, reduced gut inflammation, and increased levels of natural anti-inflammatory compounds in the body.
Mollusk shells as marine bioactive materials: Composition, bioactivities, and prospects for food and health applications
Researchers reviewed the bioactive properties of marine mollusk shells, which are generated in large quantities as seafood processing waste. They found that shell-derived compounds exhibit antioxidant, anti-inflammatory, antimicrobial, and bone-building properties, supporting potential uses as natural calcium sources and functional food ingredients. The study highlights an opportunity to turn an abundant waste material into valuable health and food science applications.
A Concise Review on Taro Mucilage: Extraction Techniques, Chemical Composition, Characterization, Applications, and Health Attributes
This review examined extraction techniques, chemical composition, characterization, and applications of mucilage from taro (Colocasia esculenta). Researchers found that taro mucilage has excellent functional properties including water-holding, oil-holding, and swelling capacities, making it useful in food, pharmaceutical, and other applications. The study suggests that taro mucilage could serve as a sustainable biopolymer alternative in various industrial applications.
The role of microplastics in the pathogenesis of inflammatory bowel diseases
This review of existing research found that tiny plastic particles we eat and drink may contribute to inflammatory bowel diseases like Crohn's disease and ulcerative colitis. The plastic bits can damage the gut lining, cause inflammation, and disrupt the healthy bacteria in our intestines. While more research is needed to confirm the connection, this suggests that reducing plastic pollution could be important for protecting our digestive health.
The potential mechanism of huazhuojiedu decoction in the treatment of ulcerative colitis based on network pharmacology and experimental validation
Researchers used network pharmacology to identify 119 active components and 146 potential targets of the traditional Chinese medicine formula Huazhuojiedu decoction relevant to ulcerative colitis, then validated key predicted mechanisms in dextran sulfate sodium-induced rat colitis models, elucidating multi-target pathways underlying the formula's clinically observed therapeutic effects.
Generating an in vitro gut model with physiologically relevant biophysical mucus properties
Researchers developed an in vitro gut model combining Caco-2 enterocyte-like cells and HT29-MTX goblet-like cells to generate mucus with physiologically relevant biophysical properties, characterizing the viscosity and pore size of the produced mucus to create a more complete model of the gastrointestinal epithelium for drug absorption and delivery research.
Dietary Curcumin Promotes Gilthead Seabream Larvae Digestive Capacity and Modulates Oxidative Status
Adding curcumin to the diet of gilthead seabream larvae improved their digestive capacity and antioxidant status. The research explores natural dietary supplements for improving fish health in aquaculture, which is relevant as farmed seafood is a source of microplastic exposure for humans.
The Potential Role and Effective Components of Sanyeqing as the Potential Therapeutic Candidates for IBD and CRC
This review examines the phytochemical constituents of Sanyeqing (a traditional medicinal plant) and their therapeutic potential for inflammatory bowel disease and colorectal cancer, identifying anti-inflammatory and anti-tumor mechanisms that could complement conventional treatments.
Influence of Microplastics on Manifestations of Experimental Chronic Colitis
Researchers studied whether consuming microplastics worsens chronic colon inflammation in mice. While microplastics alone did not cause visible damage to healthy intestines, they significantly increased the severity of colitis symptoms, including more ulcers and greater inflammatory cell infiltration, in mice with pre-existing colon inflammation. The findings suggest that microplastic exposure may be particularly concerning for individuals who already have inflammatory bowel conditions.
Mechanism of Mulberry Leaves and Black Sesame in Alleviating Slow Transit Constipation Revealed by Multi-Omics Analysis
Researchers examined how mulberry leaves and black sesame alleviate slow transit constipation in a mouse model, measuring gut motility, microbiota composition, and intestinal gene expression. Both dietary interventions increased beneficial bacteria, enhanced gut peristalsis, and upregulated genes associated with intestinal motility, supporting their traditional use for digestive health.
Influence of Microplastics on Morphological Manifestations of Experimental Acute Colitis
Researchers fed polystyrene microplastics to mice for six weeks and found that healthy mice developed changes in their colon lining, including altered mucus composition and immune cell populations. When mice with experimentally induced colitis also consumed microplastics, their intestinal inflammation was significantly more severe. The study suggests that microplastic exposure may worsen inflammatory bowel conditions.
P0455 Mucosal Microplastic Deposition is Associated with Disease Severity in Crohn’s Disease: A Pilot Study Using Multi-Modal Imaging and Spectroscopy
Researchers quantified and characterized microplastics in the intestinal mucosa of patients with Crohn's disease compared to healthy controls. The study found that microplastics were present in gut tissue across all groups, but patients with active Crohn's disease had significantly higher concentrations than those in remission or healthy individuals. The findings suggest an association between mucosal microplastic deposition and endoscopic disease severity in Crohn's disease.
Dexmedetomidine alleviates intestinal barrier dysfunction and inflammatory response in mice via suppressing TLR4/MyD88/NF-κB signaling in an experimental model of ulcerative colitis
Researchers investigated whether dexmedetomidine (DEX), a sedative agent, alleviates intestinal barrier dysfunction and inflammatory responses in a mouse model of ulcerative colitis, finding that DEX suppresses the TLR4/MyD88/NF-kB signaling pathway to reduce epithelial cell apoptosis and inflammation. The results suggest that DEX may have therapeutic potential for protecting intestinal barrier integrity in inflammatory bowel conditions.
A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals
This review explored how plant-based compounds could be used to treat ulcerative colitis by targeting mitochondrial function. Researchers discussed how dysfunctional mitochondria generate excessive reactive oxygen species that drive intestinal inflammation. While focused on therapeutic approaches rather than microplastics directly, the study is relevant to understanding how environmental stressors that damage mitochondria may contribute to gut inflammation.
The role of human intestinal mucus in the prevention of microplastic uptake and cell damage
Researchers studied how the mucus lining of the human intestine acts as a barrier against microplastic particles of different sizes and surface coatings. The mucus layer significantly reduced microplastic uptake by cells and protected against toxicity and inflammation. This study suggests that a healthy intestinal mucus layer is an important natural defense against the harmful effects of swallowed microplastics.
Microplastic effects on mouse colon in normal and colitis conditions: A literature review
This literature review examined studies on how microplastic exposure affects the mouse colon under both normal and inflammatory conditions. Evidence indicates that microplastics may contribute to intestinal inflammation and could worsen existing colitis. The review highlights the need for further research to better understand how microplastic ingestion may influence gut health in humans.
Effects of repeated intragastric administrations with heat-inactivated Mycobacterium aurum DSM 33539 on the stress-induced aggravation of dextran sulfate sodium (DSS) colitis in C57BL/6N mice
Researchers tested whether a heat-inactivated preparation of the soil bacterium Mycobacterium aurum could protect mice from stress-aggravated intestinal inflammation. They found that oral administration of M. aurum reduced the severity of stress-induced colitis and helped maintain intestinal barrier integrity. The study suggests that certain beneficial environmental bacteria may help protect gut health under stressful conditions, though more research is needed.
The Impact of Microalgae and Their Bioactive Compounds on Liver Well-being in Rats Subjected to Synthetic Phenolic Antioxidants
This review examines how microalgae and their bioactive compounds — including polysaccharides, pigments, and polyphenols — protect liver health in animal models, summarizing evidence for anti-inflammatory and antioxidant mechanisms. The authors note that algal-derived compounds show hepatoprotective effects in rodent studies, though human clinical evidence remains limited.
Impacts of microplastics on gut health: Current status and future directions
This systematic review found consistent evidence across mouse, fish, and earthworm models that microplastics disrupt gut microbiota composition, impair intestinal barrier integrity, and trigger gastrointestinal inflammation. The correlation between microplastic exposure and gut health deterioration was statistically significant across all animal models examined.
Fermented Wheat Bran Polysaccharides Improved Intestinal Health of Zebrafish in Terms of Intestinal Motility and Barrier Function
Researchers found that fermented wheat bran polysaccharides improved intestinal health in zebrafish by enhancing intestinal motility and barrier function, suggesting their potential as functional food additives for gut health.
Black Lycium barbarum polysaccharide attenuates LPS-induced intestine damage via regulation gut microbiota
Researchers studied whether a polysaccharide from black Lycium barbarum could protect against intestinal damage caused by bacterial toxins in mice. They found that the supplement alleviated intestinal tissue damage and improved gut microbiota diversity by promoting beneficial bacteria. The study suggests that this plant-derived polysaccharide may help maintain intestinal health by modulating the gut microbial community.