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Papers
4 resultsShowing papers from Second Affiliated Hospital of Guangzhou Medical University
ClearIn vivo and In vitro assessment of the retinal toxicity of polystyrene nanoplastics
Researchers found that orally ingested polystyrene nanoplastics can reach the mouse retina within just two hours and, after prolonged exposure, damage the blood-retina barrier, cause oxidative stress, and trigger cell death in retinal tissue. Tests on human retinal cells confirmed similar toxic effects, suggesting that nanoplastic exposure through food and water could pose previously unrecognized risks to eye health.
First identification of microplastics in umbilical cord blood and their direct target proteins: A pioneering discovery
In a pioneering study, researchers detected microplastics in all human umbilical cord blood samples tested, at a mean concentration of 41.128 micrograms per gram, with polystyrene, polyethylene, PVC, and polypropylene being the most common polymers. Using advanced proteomics, the study identified 84 proteins that directly bind to microplastics, with significant enrichment in hypoxia signaling pathway proteins, providing the first evidence of specific molecular targets of microplastics in fetal circulation.
Micro/nanoplastics and eye health: a review
This review examined the potential effects of micro- and nanoplastics on eye health, finding that ocular exposure can occur through direct contact and oral ingestion, with particles potentially penetrating biological barriers to reach eye tissues. Evidence indicates that these particles may induce adverse effects on the eye surface, elevate intraocular pressure, and cause retinal abnormalities, primarily through oxidative stress and inflammation mechanisms.
Polystyrene microplastics aggravate acute pancreatitis in mice
Researchers found that polystyrene microplastics aggravated acute pancreatitis in mice by amplifying inflammatory responses, with exposure at 100 and 1000 micrograms per liter worsening pancreatic damage induced by cerulein injection.