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Analysis of prediction of breast and colon cancer stemness in the treatment of chemoterapeutic agents using mathematical modeling tools
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Researchers used flow cytometry, qRT-PCR, and mathematical modeling to analyze cancer stem cell populations in colon (HCT-116) and breast (MDA-MB-231) cell lines, finding that conventional chemotherapeutics can both inhibit and promote cancer stem cell proliferation, and that polystyrene nanoplastics significantly contribute to malignant phenotype development.
Uvod: Kompleksna tumorska mikrosredina sa heterogenim vrstama ćelija predstavlja brojne izazove u terapijskom pristupu jer i nakon hemioterapije, kancerske matične ćelije CSCc ostaju vijabilne i ponovo mogu indukovati nastanak tumora i metastaza. Zbog navedenog, detaljna analiza tumorske mikrosredine i identifikacija drajver markera i ćelija sa različitim fenotipom je neophodna. Cilj: Osnovni cilj ovog istraživanja je detekcija markera koji učestvuju u terapijskom ishodu i identifikacija noksi (poliestirenska nanoplastika) koje doprinose razvoju tumora. Materijal i metode: Markeri rezistencije i malignosti koji su bili ispitivani su: CD24, CD44, ABCG2 i ALDH1. Obuhvaćena je analiza 24 različite kombinacije ovih markera kao i ispitivanje uticaja 5-fluorouracila, leukovorina, irinotekana, oksaliplatine i poliestirenske nanoplastike na modelu ćelijskih linija kancera kolona (HCT-116) i dojke (MDA-MB-231). Matematička analiza omogućila nam je bolju karakterizaciju malignog fenotipa. Rezultati: Uticaj hemioterapeutika i nanoplastike na izlečenje, nastanak i progresiju tumora, predstavljaju najznačajniji doprinos ovog istraživanja. Stepen malignosti određivan je na osnovu zastupljenosti populacije CSC, koja je definisana ekspresijom markera matičnosti metodama protočne citometrije i qRT-PCR. U proceni vijabilnosti koristili smo in vitro metode (MTT i RTCA). Zaključak: Rezultati ovog istraživanja po prvi put pokazuju da su ispitivane linije karcinoma heterogena populacija tumorskih ćelija koje sadrže i CSC. Takođe da konvencionalni hemioterapeutici mogu da pomognu ali mogu i da promovišu proliferaciju CSC. Polistirenska nanoplastika predstavlja značajnu noksu u nastanku malignog fenotipa. Implementacija matematičkog modeliranja predstavnja važan faktor u razumevanju tumora i izboru terapije.
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Researchers combined computer modeling with lab tests on human colorectal cancer cells (HCT-116) to study how polystyrene nanoplastics might affect colorectal cancer. Exposure to these nanoplastics damaged cells, increased harmful molecules called reactive oxygen species, reduced protective enzyme activity, triggered cell death, and raised levels of inflammation-related substances.
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