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Surface Modification of Polydopamine Particles with Polyethyleneimine Brushes for Enhanced Stability and Reduced Fragmentation
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This research develops a method to coat polydopamine nanoparticles with polyethylene glycol (PEG) to improve their stability and biocompatibility for potential biomedical uses. The PEG surface layer reduces particle aggregation and minimizes nonspecific protein binding, which is important for in vivo applications. The work contributes to safer nanoparticle design in contexts where plastic-derived polymer coatings interact with biological systems.
Polydopamine (Pdop) particles possess unique properties but suffer from inherent instability in aqueous environments due to the gradual release of Pdop fragments. This study demonstrated the successful enhancement of the stability and reduction in fragmentation in Pdop particles through surface engineering strategies. Specifically, we investigated the effects of polyelectrolyte multilayer (PEM) coating and polyelectrolyte (PE) brush grafting. Our results showed that PE brush grafting, particularly with long-chain polyethyleneimine (PEI), was more effective in suppressing Pdop fragment release compared to PEM coating. The L-PEI grafted Pdop particles (2.28 chains/nm2) exhibited remarkable stability across a wide pH range (3-9), with inhibition rates exceeding 90% in most cases, reaching 93% at pH 5. Furthermore, a direct correlation between PEI grafting density (0.64 to 2.28 chains/nm2) and inhibition rate was observed, with higher densities yielding greater stability. These findings offer a promising approach for stabilizing Pdop particles for diverse applications.
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Researchers used dynamic light scattering to show that surface chemistry dictates nanoplastic fate in water: positively charged amine-coated particles remain stable across a wide salinity range, while negatively charged plain and carboxylated particles aggregate into large clusters as ionic strength or salinity increases.
Nanoplastic transport in aqueous environments: The role of chemo-electric properties and hydrodynamic forces for nanoplastic-mineral interaction.
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This study examined the role of chemo-electric properties and hydrodynamic forces in controlling nanoplastic interactions with mineral surfaces in aquatic environments. The findings characterize transport mechanisms relevant to understanding nanoplastic fate in rivers and groundwater systems.
The Effects of Nanoplastics on the Dopamine System of Cerebrocortical Neurons
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Researchers studied how nanoplastics affect the dopamine system in brain neurons grown in the lab. They found that nanoplastics accumulated inside neurons in a dose-dependent manner and altered the levels of proteins involved in dopamine signaling. These results suggest that nanoplastic exposure could potentially interfere with brain chemistry, though more research is needed to understand what this means for human health.
Stabilization of Fragmental Polystyrene Nanoplastic by Natural Organic Matter: Insight into Mechanisms
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This study investigated how natural organic matter stabilizes fragmental polystyrene nanoplastics in aqueous environments, finding that humic and fulvic acid coatings reduce aggregation and enhance colloidal stability, affecting nanoplastic transport and bioavailability.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.