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Effects of TBBPA Exposure on Neurodevelopment and Behavior in Mice
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This study found that perinatal exposure to the flame retardant TBBPA at environmentally relevant doses impaired neurodevelopment in mice, with male offspring showing deficits in motor function, memory, and social interaction, and females showing motor impairment, accompanied by changes in gene expression linked to behavioral abnormalities.
Tetrabromobisphenol A (TBBPA) is a brominated flame retardant widely used in consumer products. TBBPA is often detected in soil, water, organisms, and even in human blood and breast milk. Hence, it is accessible to developing fetuses and nursing offspring after maternal exposure. The reported evidence for the endocrine disruption of TBBPA in the brain has raised concerns regarding its effects on neurodevelopmental and behavioral functions. This study investigated the effects of TBBPA exposure on neurodevelopment. A cell-based developmental neurotoxicity assay was performed to determine whether TBBPA is a developmental neurotoxicant. The assay revealed TBBPA to be a developmental neurotoxicant. C57BL/6N maternal mice were administered TBBPA at 0, 0.24, and 2.4 mg/kg during pregnancy and lactation, and their offspring underwent behavioral testing. The behavioral experiments revealed sex-specific effects. In females, only a deterioration of the motor ability was observed. In contrast, deteriorations in motor function, memory, and social interaction were noted in males. Furthermore, we validated changes in the expression of genes associated with behavioral abnormalities, confirming that perinatal exposure to TBBPA, at the administered doses, can affect neurodevelopment and behavior in offspring. These findings highlight the need for more in-depth and multifaceted research on the toxicity of TBBPA.
More Papers Like This
A Review on Tetrabromobisphenol A: Human Biomonitoring, Toxicity, Detection and Treatment in the Environment
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This review summarizes the current evidence on tetrabromobisphenol A (TBBPA), a flame retardant chemical found in consumer products that acts as an endocrine disruptor. Researchers compiled findings on how TBBPA has been detected in human samples and various environments, along with its toxic effects on hormone systems. The review highlights that research on TBBPA exposure routes, detection methods, and treatment technologies is still in early stages and needs further development.
Association of tetrabromobisphenol A (TBBPA) with micro/nano-plastics: A review of recent findings on ecotoxicological and health impacts
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This review examines how tetrabromobisphenol A (TBBPA), a widely used flame retardant found in plastic products, binds to micro and nanoplastics in the environment. When TBBPA hitches a ride on microplastics, the combined effect on organisms and ecosystems is often worse than either contaminant alone. Since TBBPA is an additive in many plastic products, the findings highlight how microplastics can carry harmful chemicals directly into the body.
Toxic Effects of Tetramethyl Bisphenol A on Embryonic–Larval Development of Zebrafish (Danio rerio)
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Researchers exposed zebrafish embryos to the bisphenol A alternative tetramethyl bisphenol A (TMBPA) and found it reduced hatching rates, stunted larval growth, impaired swimming behavior, and disrupted gene expression linked to antioxidant defense, thyroid hormone signaling, cardiac development, and stress response pathways, raising environmental safety concerns about this emerging plastic additive.
The Effects of Tetrabromobisphenol A (TBBPA) on the Mussel Mytilus galloprovincialis: A Multi-Biomarker Approach
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Scientists exposed Mediterranean mussels to the flame retardant tetrabromobisphenol A (TBBPA) for 28 days to assess its toxic effects using multiple biological markers. Researchers found that TBBPA caused measurable changes in the mussels' antioxidant defenses, immune responses, and cellular health. The study suggests that this widely used industrial chemical poses a meaningful risk to marine bivalves and the coastal ecosystems they inhabit.
Enhanced adsorption of tetrabromobisphenol a (TBBPA) on cosmetic-derived plastic microbeads and combined effects on zebrafish
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Scientists investigated how cosmetic microbeads adsorb the flame retardant TBBPA and then tested the combined effect on zebrafish, finding that microbeads enhanced TBBPA bioavailability and caused greater developmental toxicity and endocrine disruption than TBBPA exposure alone.
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