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Bisphenol F exposure induced vascular toxicity through intestinal microbiota imbalance
Hellenic Journal of Cardiology
2025
Jianlong Yan,
Yanbin Pan,
Hannah Ji-Jia Liu,
Jie Yuan,
Jie Chen,
Yannan Gao,
Chaolan Lin,
Feng Lin,
Rongning Wang,
Yaqiong He,
Caiping Wang,
Cong Xu,
Tangzhiming Li,
Pengfei Zhang,
Lan Yu,
Wenming Shao,
Xinli Pang,
Da Yin,
Xin Sun,
Weixiang Luo
Summary
Researchers demonstrated that bisphenol F (BPF) exposure triggers and worsens vascular calcification by disrupting the gut microbiota, identifying the gut-vascular axis as a key mechanistic pathway linking plastic-associated chemical exposure to cardiovascular disease risk.
The results here elucidate the mechanism underlying BPF-triggered or BPF-aggravated VC through the gut-vascular axis and provide a theoretical basis for cardiovascular disease risk assessment in humans.