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Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion
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Researchers used multi-omics analysis to study how nanoplastics affect mice with chronic blood vessel occlusion in the brain, modeling the interaction between plastic pollution and existing cardiovascular conditions. They found that nanoplastic exposure worsened behavioral deficits, increased brain inflammation, and disrupted gut microbiome balance in the affected mice. The study suggests that nanoplastic contamination may pose heightened risks for individuals already living with chronic vascular conditions.
Accumulation of nanoplastics (NPs) poses a severe threat to the homeostasis of the internal environment in patients with chronic diseases. The effects of NP contamination on health in chronically ill populations must urgently be elucidated. In this study, NPs injected via the tail vein were distributed in the brain and internal organs in a mouse model of chronic internal carotid occlusion. Mice with chronic internal carotid artery occlusion exposed to NPs showed behavioral abnormalities, such as depression and anxiety, thus indicating detrimental effects of NPs on the brain. Subsequently, we used proteomics and metabolomics to analyze the specific mechanisms underlying the damaging effects of NP deposition in the brain. The findings helped explain the differences in the underlying biochemical responses at the microscopic level in mice after NP exposure. The NPs not only accumulated in the brain and caused pathologic damage, but also contributed to accelerating atherosclerosis in the mouse model of internal carotid artery occlusion. This work confirms the risk of NPs in a model of internal carotid artery occlusion and elucidates the mechanism underlying this harm; moreover, it provides theoretical support for developing strategies to decrease microplastic intake in patients with internal carotid artery occlusion.
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Researchers fabricated nanoplastics (~500 nm) and microplastics (~2 µm) and fed them to mice, using single-cell RNA sequencing of gut and brain tissue to find that nanoplastic oral exposure induced intestinal IL-1β-producing macrophages, which in turn impaired brain function, revealing an indirect gut-immune-brain mechanism of nanoplastic toxicity.
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Researchers discovered that microplastics in the bloodstream can cause blood clots in the brain by getting swallowed by immune cells that then block tiny blood vessels. These blockages reduced blood flow and caused neurological problems in mice. This reveals a new way microplastics may harm the brain, not by crossing into brain tissue directly, but by disrupting blood circulation.
Microplastics block blood flow in the brain, mouse study reveals
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Researchers used real-time imaging in mice to demonstrate that microplastics can accumulate inside cells, causing them to form clumps that block blood flow in the brain and impair movement. The findings provide direct visual evidence linking microplastic ingestion to cerebrovascular obstruction and neurological effects in a mammalian model.
Oxidized/unmodified-polyethylene microplastics neurotoxicity in mice: Perspective from microbiota-gut-brain axis
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Mice given polyethylene microplastics by mouth for 28 days showed behavior changes, weakened gut and blood-brain barriers, and inflammation in brain and intestine. Oxidized, weathered particles caused more harm than unmodified ones. Giving Lactobacillus plantarum DP189 with a prebiotic partially reversed the changes in these mice.
Nanoplastics-induced neurotoxicity: neurovascular dysfunction, cognitive impairment, and mechanisms of cell death.
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This review summarizes existing research on how tiny plastic particles called nanoplastics may affect the brain. Studies in lab models suggest these particles can disrupt the brain's protective barrier, trigger cell stress and death, and interfere with brain cell communication, which researchers link to memory and behavior problems in experimental models.
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