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The Plasticizer Dibutyl Phthalate (DBP) Impairs Pregnancy Vascular Health: Insights into Calcium Signaling and Nitric Oxide Involvement
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Researchers investigated how the plasticizer dibutyl phthalate (DBP), found in household products and cosmetics, affects blood vessel function during pregnancy using human umbilical arteries. DBP induced concentration-dependent vasorelaxation through pathways involving nitric oxide signaling and calcium handling, suggesting it may alter arterial tone regulation and pose cardiovascular risks during pregnancy.
Dibutyl phthalate (DBP) is used as a plasticizer to enhance flexibility in several household products, cosmetics, and food-contact materials. Due to its harmful effects, DBP is restricted or banned in children's products and food items, particularly in Europe. Due to its endocrine disruptor properties and considering its ability to cross the placental barrier, it is imperative to study DBP's vascular effects in pregnancy, given the vulnerability of this period. Thus, this study investigated the potential effects of DBP on the cardiovascular system using umbilical arteries from healthy pregnant women. Specifically, the impact of DBP on the vascular reactivity after both rapid and 24 h DBP exposure was analyzed, as well as the contractility and the cell viability of vascular smooth muscle cells (VSMC). DBP did not exhibit overt cytotoxic effects on VSMCs, possibly due to its adsorption onto polystyrene surfaces, potentially limiting bioavailability. Interestingly, DBP induced vasorelaxation in a concentration-dependent manner. Although mechanistic insights remain to be fully elucidated, the results suggest the involvement of pathways associated with nitric oxide signaling and calcium handling. Overall, DBP exposure appears to modulate arterial tone regulation, which may have implications for vascular function during pregnancy.
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Micro and nanoplastic inhalation during pregnancy elicits uterine endothelial dysfunction in Sprague Dawley rats by impeding nitric oxide signaling
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Researchers found that inhaling micro and nanoplastics during pregnancy in rats impaired blood vessel function in the uterus and reduced fetal growth. The exposure substantially decreased levels of activated endothelial nitric oxide synthase, a key enzyme for healthy blood vessel dilation. The study suggests that plastic particle inhalation during pregnancy may compromise uterine blood flow through disruption of nitric oxide signaling.
Probing the Cardiovascular Toxic Effects of Long-Term Exposure to Dibutyl Phthalate in Sprague-Dawley Rats Based on Oxidative Inflammation and Metabolic Pathways: Implications for the Heart and Blood Vessel
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This study investigates the effects of prolonged microplastic exposure on cardiovascular health, examining how particles accumulate in cardiac tissues and disrupt normal function. Researchers documented toxic responses including inflammation, oxidative stress, and structural changes in heart and vascular tissue. The findings raise concern about the long-term cardiovascular risks posed by chronic microplastic exposure in humans and animals.
Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review
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This review examines the endocrine-disrupting effects of bisphenol A (BPA), a common plastic chemical, on the cardiovascular system. Evidence indicates that BPA can impair heart function through disruption of ion channels, calcium handling, and oxidative stress, and that BPA exposure is associated with increased risk of cardiovascular conditions including atherosclerosis and hypertension.
Systemic investigation of di-isobutyl phthalate (DIBP) exposure in the risk of cardiovascular via influencing the gut microbiota arachidonic acid metabolism in obese mice model
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Researchers studied how di-isobutyl phthalate, a plasticizer chemical commonly found in food and water, affects cardiovascular health in both normal and obese mice. They found that the compound disrupted gut bacteria and altered fat metabolism pathways, with obese mice showing more severe effects including increased cardiovascular risk markers. The study suggests that exposure to this common plastic-related chemical may contribute to heart disease risk, particularly in people who are already overweight.
Uterine Microvascular Dysfunction After Plastic Particle Inhalation
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Researchers investigated uterine microvascular reactivity in female Sprague Dawley rats after acute inhalation of aerosolized plastic particles to assess cardiovascular effects of micro- and nanoplastic exposures. The study aimed to define mechanisms of microvascular dysfunction caused by plastic aerosols, building on prior epidemiological work linking airborne particulate matter to adverse cardiovascular outcomes.
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