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Video S6: Trojan Horse Effect of Biologically Aged Microplastics-An Intracellular Carrier of LPS for Licensing Noncanonical Inflammasome Activation
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This video supplemental documents forces applied to LPS molecules bound to the surface of biologically aged microplastics along the z-axis, accompanying research on the Trojan Horse effect of aged microplastics as intracellular LPS carriers that activate noncanonical inflammasome pathways. The data supports mechanistic understanding of how weathered microplastics potentiate inflammatory immune responses.
Video S6. Forces applied to LPS bound to the surface of aged MPs along the -axis
More Papers Like This
Supporting information file for: Trojan Horse Effect of Biologically Aged Microplastics-An Intracellular Carrier of LPS for Licensing Noncanonical Inflammasome Activation
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Supporting data for a Trojan horse study showed that biologically aged microplastics—which accumulate a protein corona and adsorb lipopolysaccharide (LPS)—activate the noncanonical NLRP3/caspase-11 inflammasome pathway intracellularly, exacerbating intestinal inflammation in colitis models. This is highly significant to microplastic health research as it demonstrates that environmental aging transforms microplastics into active intracellular carriers of bacterial toxins, amplifying immune pathology beyond the particle effect alone.
Trojan Horse Effect of Biologically Aged Microplastics-An Intracellular Carrier of LPS for Licensing Noncanonical Inflammasome Activation
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Researchers aged polystyrene microplastics biologically inside tissue and found the particles accumulated lipopolysaccharide (LPS) from bacteria; they then showed these biologically-aged particles could deliver LPS into cells to activate the non-canonical inflammasome pathway. This "Trojan horse" mechanism—absent with pristine or briefly-aged particles—suggests long-term tissue-trapped microplastics may trigger chronic inflammatory disease.
Video S2. Interaction between aged MPs and LP
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After one year in artificial body fluids, polystyrene microplastics showed increased surface roughness and hydrophilicity that enhanced adhesion of lipopolysaccharide, a bacterial toxin. When phagocytosed by macrophages, these aged microplastic-LPS complexes triggered inflammasome activation and pyroptosis, and worsened colitis severity in mice, identifying aged microplastics as 'Trojan horses' for amplifying inflammatory responses.
Environmental Nanoplastics Induce Microglia Activation and Inflammatory Responses
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Tiny plastic particles from pollution (called nanoplastics) can travel all the way into the brain, where new research shows they trigger the brain's immune cells to become overactive and cause inflammation. This matters because chronic brain inflammation has been linked to conditions like memory problems and neurodegenerative disease, raising concerns about the long-term effects of the plastic pollution we're increasingly exposed to in daily life.
Potential Health Risks of Micro-Nanoplastics and Persistent Organic Pollutants: A Review of Exposure Pathways and Toxic Effects
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This review examines how micro- and nanoplastics can enhance the bioavailability of persistent organic pollutants through a Trojan horse effect, leading to combined inflammatory, cellular, and metabolic toxic effects that threaten human health beyond what either contaminant causes alone.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.