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Supporting information file for: Trojan Horse Effect of Biologically Aged Microplastics-An Intracellular Carrier of LPS for Licensing Noncanonical Inflammasome Activation

International Journal of Food Microbiology 2025
Qi Li, Xiaofeng Wang, Yaqing Xu, Wuqiong Zhang, Yingnan Liu, Su Li, Xiaoman Suo, Fangfang Liu, Yanqiao Zeng, Massimiliano Galluzzi, Víctor F. Puntes, Yan-Zhong Chang, Yingze Wang, Guofang Zhang, Yang Li

Summary

Supporting data for a Trojan horse study showed that biologically aged microplastics—which accumulate a protein corona and adsorb lipopolysaccharide (LPS)—activate the noncanonical NLRP3/caspase-11 inflammasome pathway intracellularly, exacerbating intestinal inflammation in colitis models. This is highly significant to microplastic health research as it demonstrates that environmental aging transforms microplastics into active intracellular carriers of bacterial toxins, amplifying immune pathology beyond the particle effect alone.

Body Systems
Digestive

SEM, EDS, py-GCMS, surface functional group analysis, characterization of MPs, surface roughness analysis, protein adsorption and LPS, binding and binding force of pristine and aged microplastics to LPS, caspase-11-dependent sensing progression of colitis, gating strategies, Rhodamine 123 loading, and densitometric quantification

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