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Curcumin attenuates nanoparticle-induced renal injury via the PI3K/AKT signaling pathway

Eos 2026
Huiyuan Rui, Xinran xu, Shuhui Liu, Xueli Gao, Xiaowen Jiang, Wenhui Yu

Summary

Curcumin was found to protect kidney cells from polystyrene nanoplastic-induced injury by activating the PI3K/AKT signaling pathway, demonstrated through both in vitro and in vivo experiments using network pharmacology. This is significant for microplastic pollution research as it identifies a potential natural therapeutic intervention against the nephrotoxic effects of nanoplastic exposure.

Polymers
PS
Body Systems
Renal
Study Type In vivo

Exposure to polystyrene nanoplastics (PS-NPs) endangers human health, so exploring curcumin (Cur)'s nephroprotective effects against PS-NPs-induced injury is crucial. This research integrated network pharmacology with in vitro and in vivo...

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