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Combined exposure to microplastics and pesticides with endocrine-disrupting potential: evidence of interaction, reproductive biomarkers, and tissue bioaccumulation in humans and animal models
Summary
This systematic review protocol, following PRISMA-P and PRISMA-S guidelines, will evaluate evidence for interactions between microplastics and endocrine-disrupting pesticides and their combined effects on reproductive biomarkers and tissue bioaccumulation in humans and animal models. The review addresses a critical knowledge gap regarding how these co-occurring contaminants may amplify each other's harmful effects within the broader exposome framework.
Systematic review protocol evaluating the evidence of interaction between microplastics and pesticides with endocrine-disrupting potential and their association with reproductive biomarkers and tissue bioaccumulation in humans and animal models. The project follows PRISMA-P and PRISMA-S guidelines and will be prospectively registered in PROSPERO. The review will synthesize evidence from human observational studies and experimental animal studies to assess potential additive, synergistic, or potentiating interactions between environmental contaminants within the exposome framework. All materials including the protocol, search strategies, data extraction templates, and PRISMA screening workflow will be deposited in this repository to ensure transparency and reproducibility.