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Combined exposure to microplastics and pesticides with endocrine-disrupting potential: evidence of interaction, reproductive biomarkers, and tissue bioaccumulation in humans and animal models
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This systematic review protocol, following PRISMA-P and PRISMA-S guidelines, will evaluate evidence for interactions between microplastics and endocrine-disrupting pesticides and their combined effects on reproductive biomarkers and tissue bioaccumulation in humans and animal models. The review addresses a critical knowledge gap regarding how these co-occurring contaminants may amplify each other's harmful effects within the broader exposome framework.
Systematic review protocol evaluating the evidence of interaction between microplastics and pesticides with endocrine-disrupting potential and their association with reproductive biomarkers and tissue bioaccumulation in humans and animal models. The project follows PRISMA-P and PRISMA-S guidelines and will be prospectively registered in PROSPERO. The review will synthesize evidence from human observational studies and experimental animal studies to assess potential additive, synergistic, or potentiating interactions between environmental contaminants within the exposome framework. All materials including the protocol, search strategies, data extraction templates, and PRISMA screening workflow will be deposited in this repository to ensure transparency and reproducibility.
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Combined exposure to microplastics and pesticides with endocrine-disrupting potential: evidence of interaction, reproductive biomarkers, and tissue bioaccumulation in humans and animal models
AI summary Read the abstract
This systematic review protocol will synthesize evidence from human and animal studies on the combined effects of microplastic and endocrine-disrupting pesticide co-exposure on reproductive biomarkers and tissue bioaccumulation, following PRISMA-P and PROSPERO registration guidelines. This research addresses a critical gap in understanding how microplastics act as vectors for pesticide delivery to reproductive tissues, potentially amplifying hormonal disruption beyond either contaminant alone.
01_protocol
AI summary Read the abstract
This systematic review protocol establishes standardized methods for extracting and synthesizing data from studies on combined microplastic and endocrine-disrupting pesticide exposure, with dual-reviewer verification and full transparency in search strategy documentation. Rigorous protocols like this are essential for producing reliable meta-evidence on the health impacts of microplastic-pesticide co-exposure, an area currently hampered by inconsistent methodologies.
01_protocol
AI summary Read the abstract
This protocol establishes the framework for a systematic review investigating combined exposure to microplastics and endocrine-disrupting pesticides and their effects on reproductive biomarkers and tissue bioaccumulation. Examining these contaminants together reflects real-world co-exposure conditions and may reveal interaction effects missed by studies examining each pollutant in isolation.
02_search_strategy
AI summary Read the abstract
This component documents comprehensive database search strategies for identifying studies on combined microplastic and endocrine-disrupting pesticide exposure, using controlled vocabulary and Boolean operators across five major scientific databases. Transparent, reproducible search strategies are foundational to systematic reviews that will ultimately inform regulatory policy on the compounded health risks of microplastic-pesticide co-contamination.
02_search_strategy
AI summary Read the abstract
This component documents comprehensive search strategies across five major academic databases for identifying studies on combined microplastic and pesticide exposures, following PRISMA-S guidelines with controlled vocabulary and free-text terms. Rigorous and transparent search strategies are foundational to producing a systematic review that accurately captures the state of evidence on these co-occurring environmental contaminants.
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