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Combined exposure to microplastics and pesticides with endocrine-disrupting potential: evidence of interaction, reproductive biomarkers, and tissue bioaccumulation in humans and animal models
Summary
This systematic review protocol will synthesize evidence from human and animal studies on the combined effects of microplastic and endocrine-disrupting pesticide co-exposure on reproductive biomarkers and tissue bioaccumulation, following PRISMA-P and PROSPERO registration guidelines. This research addresses a critical gap in understanding how microplastics act as vectors for pesticide delivery to reproductive tissues, potentially amplifying hormonal disruption beyond either contaminant alone.
Systematic review protocol evaluating the evidence of interaction between microplastics and pesticides with endocrine-disrupting potential and their association with reproductive biomarkers and tissue bioaccumulation in humans and animal models. The project follows PRISMA-P and PRISMA-S guidelines and will be prospectively registered in PROSPERO. The review will synthesize evidence from human observational studies and experimental animal studies to assess potential additive, synergistic, or potentiating interactions between environmental contaminants within the exposome framework. All materials including the protocol, search strategies, data extraction templates, and PRISMA screening workflow will be deposited in this repository to ensure transparency and reproducibility.