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The effect of polystyrene nanoplastic on ion channels and mucus secretion – insights from Caco-2 cell model
Colloids and Surfaces C Environmental Aspects
2026
Gabriela Weglinska,
Jakub Hoser,
Piotr Bednarczyk,
Mirosław Zając
Summary
Polystyrene nanoplastics modulated CFTR and TMEM16A ion channel activity in human intestinal epithelial (Caco-2) cells, leading to increased mucus secretion. This finding suggests that ingested nanoplastics can directly disrupt gut epithelial physiology, with potential consequences for intestinal barrier integrity and the microbiome in exposed individuals.
Polymers
Polystyrene nanoplastics modulate CFTR and TMEM16A channel activity in a human intestinal epithelial cell model, leading to increased mucus secretion.