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Integrative Network Toxicology and Molecular Docking Elucidate the Molecular Mechanisms and Immune Implications of Diethyl Terephthalate in Bladder Cancer
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Researchers applied network toxicology and molecular docking to map how diethyl terephthalate — a degradation product that can migrate from PET plastics — may interact with immune and oncogenic pathways implicated in bladder cancer, identifying key molecular targets for further experimental validation.
Objective Diethyl terephthalate (DET) is a diester small molecule that may originate as a by-product or a degradation/migration component from polyethylene terephthalate (PET)-related materials during their lifecycle processes such as synthesis, processing, use, and recycling. However...
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