Integrative Network Toxicology and Molecular Docking Elucidate the Molecular Mechanisms and Immune Implications of Diethyl Terephthalate in Bladder Cancer

Nanjie Li; Lu Ding; Hui Dong; Xusheng Zhang; Jiawei Wang; Huifeng Wang

doi:10.21203/rs.3.rs-8349736/v1

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Integrative Network Toxicology and Molecular Docking Elucidate the Molecular Mechanisms and Immune Implications of Diethyl Terephthalate in Bladder Cancer

The Journal of Physical Chemistry B 2026

Nanjie Li, Lu Ding, Hui Dong, Xusheng Zhang, Jiawei Wang, Huifeng Wang

Summary

Researchers applied network toxicology and molecular docking to map how diethyl terephthalate — a degradation product that can migrate from PET plastics — may interact with immune and oncogenic pathways implicated in bladder cancer, identifying key molecular targets for further experimental validation.

Polymers

PE PET

Body Systems

Immune

Objective Diethyl terephthalate (DET) is a diester small molecule that may originate as a by-product or a degradation/migration component from polyethylene terephthalate (PET)-related materials during their lifecycle processes such as synthesis, processing, use, and recycling. However...

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