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Polystyrene microplastics induce skeletal muscle atrophy through disruption of anabolic signaling and mitochondrial function
Toxicological Research
2026
Soo-Young Choi,
Jiyoung Yeo,
Yu-Jin Heo,
Hae-In Lee,
Min-Kyung Nam,
Seung-Ah Yoo,
Mi-Kyung Lee
Summary
Researchers exposed muscle cells to polystyrene microplastics and found dose-dependent muscle atrophy driven by suppressed IGF-1/PI3K/Akt/mTOR anabolic signaling, elevated oxidative stress, and mitochondrial dysfunction—effects comparable to the steroid dexamethasone—suggesting microplastics may be an unrecognized environmental contributor to muscle wasting.
Polymers
Body Systems