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Fluorometric determination of ciprofloxacin using molecularly imprinted polymer and polystyrene microparticles doped with europium(III)(DBM)phen.
Summary
Researchers developed a fluorometric sensor using molecularly imprinted polymer particles combined with europium(III)-doped polystyrene microparticles to detect the antibiotic ciprofloxacin in fish samples. The sensor detects ciprofloxacin linearly from 0.5 to 100 micrograms per liter with a detection limit of 92 nanograms per liter, offering a sensitive tool for monitoring antibiotic residues in seafood.
The authors describe a microparticle-based system for the detection of the fluoroquinolone antibiotic ciprofloxacin. The method is using the tris(dibenzoylmethane)(1,10-phenanthroline)europium(III) luminophore in polystyrene microparticles along with a molecularly imprinted polymer (MIP) for ciprofloxacin. If ciprofloxacin is captured by the MIP, it quenches the fluorescence of the luminophores. Fluorescence drops linearly in the 0.5-100 μg L ciprofloxacin concentration range, and the detection limit is 92 ng L. The method was applied to the analysis of fish samples to assess the analytical performance of the probe. Recoveries ranged from 85.4 to 86.6%, and relative standard deviations between 2.1 and 3.9% (for n = 5). Graphical abstract Schematic presentation of a microparticle-based probe using the tris(dibenzoylmethane)(1,10-phenanthroline)europium(III) luminophore in polystyrene particles along with a molecularly imprinted polymer for ciprofloxacin. After removal of template, carboxylic groups left in the probe can bind to ciprofloxacin through hydrogen bonds.