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Maternal nutrition and offspring lung health: sex-specific pathway modulation in fibrosis, metabolism, and immunity
Summary
Researchers examined how a high-sugar maternal diet during pregnancy affects lung development in offspring, finding that the damage follows sex-specific patterns. The study identified disruptions in pathways involved in fibrosis, metabolism, immunity, and cell death that differed between male and female offspring. The findings underscore the importance of balanced maternal nutrition during pregnancy for promoting long-term respiratory health.
Maternal HSD induces sex-specific lung injury in offsprings by disrupting critical pathways involved in fibrosis, metabolism, immunity, and apoptosis. The combination of transcriptomic and orthogonal data underscores the need for balanced maternal nutrition during pregnancy to promote long-term respiratory health in offsprings. These results provide new insights into the sex-specific vulnerabilities to lung disease arising from maternal diet.
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