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Tissue-Specific Biomarker Responses in the Blue Mussel Mytilus spp. Exposed to a Mixture of Microplastics at Environmentally Relevant Concentrations

Frontiers in Environmental Science 2019 164 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Messika Revel, Messika Revel, Messika Revel, Messika Revel, Messika Revel, Messika Revel, Messika Revel, Messika Revel, Rossana Sussarellu, Rossana Sussarellu, Messika Revel, Catherine Mouneyrac, Messika Revel, Fabienne Lagarde Messika Revel, Catherine Mouneyrac, Fabienne Lagarde Messika Revel, Catherine Mouneyrac, Amélie Châtel, Catherine Mouneyrac, Amélie Châtel, Catherine Mouneyrac, Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Amélie Châtel, Fabienne Lagarde Fabienne Lagarde Amélie Châtel, Amélie Châtel, Hanane Perrein-Ettajani, Catherine Mouneyrac, Fabienne Lagarde Hanane Perrein-Ettajani, Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Amélie Châtel, Amélie Châtel, Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Amélie Châtel, Catherine Mouneyrac, Catherine Mouneyrac, Catherine Mouneyrac, Catherine Mouneyrac, Fabienne Lagarde Catherine Mouneyrac, Messika Revel, Messika Revel, Hanane Perrein-Ettajani, Amélie Châtel, Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Hanane Perrein-Ettajani, Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Messika Revel, Catherine Mouneyrac, Catherine Mouneyrac, Catherine Mouneyrac, Catherine Mouneyrac, Catherine Mouneyrac, Mélanie Bruneau, Mélanie Bruneau, Mélanie Bruneau, Mélanie Bruneau, Mélanie Bruneau, Mélanie Bruneau, Mélanie Bruneau, Mélanie Bruneau, Fabienne Lagarde Hanane Perrein-Ettajani, Fabienne Lagarde Amélie Châtel, Farida Akcha, Farida Akcha, Fabienne Lagarde Farida Akcha, Farida Akcha, Fabienne Lagarde Amélie Châtel, Catherine Mouneyrac, Amélie Châtel, Amélie Châtel, Fabienne Lagarde Fabienne Lagarde Amélie Châtel, Hanane Perrein-Ettajani, Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Catherine Mouneyrac, Amélie Châtel, Amélie Châtel, Catherine Mouneyrac, Messika Revel, Fabienne Lagarde Catherine Mouneyrac, Messika Revel, Fabienne Lagarde Catherine Mouneyrac, Mélanie Bruneau, Catherine Mouneyrac, Rossana Sussarellu, Rossana Sussarellu, Rossana Sussarellu, Mélanie Bruneau, Catherine Mouneyrac, Rossana Sussarellu, Farida Akcha, Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Amélie Châtel, Amélie Châtel, Priscilla Decottignies, Amélie Châtel, Catherine Mouneyrac, Julien Rouxel, Julien Rouxel, Farida Akcha, Fabienne Lagarde Fabienne Lagarde Priscilla Decottignies, Fabienne Lagarde Katherine Costil, Amélie Châtel, Bruno Cognie, Katherine Costil, Amélie Châtel, Amélie Châtel, Amélie Châtel, Hanane Perrein-Ettajani, Fabienne Lagarde Amélie Châtel, Fabienne Lagarde Fabienne Lagarde Amélie Châtel, Priscilla Decottignies, Rossana Sussarellu, Fabienne Lagarde Bruno Cognie, Priscilla Decottignies, Rossana Sussarellu, Amélie Châtel, Fabienne Lagarde Fabienne Lagarde Amélie Châtel, Amélie Châtel, Amélie Châtel, Catherine Mouneyrac, Fabienne Lagarde Bruno Cognie, Bruno Cognie, Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Fabienne Lagarde Amélie Châtel, Amélie Châtel, Fabienne Lagarde Catherine Mouneyrac, Amélie Châtel, Amélie Châtel, Fabienne Lagarde Amélie Châtel, Fabienne Lagarde Fabienne Lagarde Catherine Mouneyrac, Amélie Châtel, Amélie Châtel, Catherine Mouneyrac, Fabienne Lagarde Amélie Châtel, Amélie Châtel, Amélie Châtel, Amélie Châtel, Fabienne Lagarde Fabienne Lagarde Amélie Châtel, Fabienne Lagarde

Summary

Researchers exposed blue mussels to an environmentally relevant mixture of polyethylene and polypropylene microplastics at three concentrations and examined tissue-specific responses over 10 days of exposure and 10 days of depuration. They found that microplastics triggered different antioxidant responses in the digestive gland versus the gills, with some evidence of DNA damage and immune system changes. The study highlights that even low, environmentally realistic concentrations of microplastics can induce measurable biochemical stress in marine bivalves.

Polymers

PE PP

Body Systems

Digestive Immune

Models

Invertebrate other

Study Type Environmental

The impact of a microplastic (MPs) mixture composed of polyethylene (PE) and polypropylene (PP) plastic particles, prepared from commercially available products, was evaluated in blue mussels Mytilus spp. exposed to three environmentally relevant concentrations: 0.008µg Lˉ¹ (low), 10 µg Lˉ¹ (medium) and 100 µg Lˉ¹ (high). Organisms were exposed for 10 days followed by 10 days of depuration in clean seawater under controlled laboratory conditions. The evaluation of MP effects on mussel clearance rate, tissue structure, antioxidant defences, immune and digestive parameters, and DNA integrity were investigated while the identification of plastic particles in mussel tissues (gills, digestive gland, and remaining tissues), and biodeposits (faeces and pseudofaeces) was performed using infrared microscopy (µFT-IR). Results showed the presence of MPs only in the digestive gland of mussels exposed to the highest tested concentration of MPs with a mean of 0,75 particle/mussel (after the 10 days of exposure). In biodeposits, PE and PP particles were detected following exposure to all tested concentrations confirming the ingestion of MPs by the organisms. A differential response of antioxidant enzyme activities between digestive gland and gills was observed. Significant increases in superoxide dismutase (SOD) and catalase (CAT) activities were measured in the digestive gland of mussels exposed to the low (0.008µg Lˉ¹) and medium (10 µg Lˉ¹) concentrations of MPs and in the gills from mussels exposed to the highest concentration (100 µg Lˉ¹) of MPs that could be indicative of a change in the redox balance. Moreover, an increase in acid phosphatase activity was measured in hemolymph of mussels exposed to 0.008 and 10 µg Lˉ¹ concentrations. No significant difference was observed in the clearance rate, and histopathological parameters between control and exposed mussels. This study brings new insights on the potential sublethal impacts of MPs at environmentally relevant concentrations in marine bivalves.

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