We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Polystyrene nanoplastics alter the cytotoxicity of human pharmaceuticals on marine fish cell lines
AI summary Read the abstract
Researchers exposed marine fish cell lines to polystyrene nanoplastics and found that while the nanoplastics alone were not directly toxic, they significantly altered the cytotoxicity of human pharmaceuticals, with one cell line proving more sensitive than the other, underscoring how nanoplastics can change the hazard profile of co-occurring chemical pollutants.
There is an increasing concern on the consequences of the presence of micro(nano)plastics to marine organisms. The present study aimed to provide information on the effects of polystyrene nanoplastics (PSNPs) to fish cells alone and combined with human pharmaceuticals, other emerging contaminants, using as biological models marine fish cell lines SAF-1 and DLB-1. Cells were exposed for 24 h to 100 nm PSNPs, starting at 0.001 up to 10 mg/L, to assess effects on viability and activity of catalase (antioxidant defense) and glutathione S-transferases (phase II biotransformation and antioxidant defense). The viability of cells was also evaluated after exposure to human pharmaceuticals alone and combined with PSNPs. Overall, PSNPs failed to be cytotoxic but data proved their ability to alter the toxicity of human pharmaceuticals. DLB-1 was the most sensitive cell line to PSNPs. Data support the use of marine fish cell lines in the study of the effects of micro(nano)plastics.
More Papers Like This
Functionalized Nanoplastics (NPs) Increase the Toxicity of Metals in Fish Cell Lines
AI summary Read the abstract
Researchers tested whether functionalized nanoplastics increase the toxicity of metals like arsenic and methylmercury in fish cell lines. The study found that amino-functionalized polystyrene nanoparticles were the most cytotoxic on their own and significantly enhanced the toxic effects of metals when combined, suggesting that nanoplastics can act as carriers that amplify the harm of co-occurring pollutants.
Nanoplastics increase the toxicity of a pharmaceutical, at environmentally relevant concentrations – A mixture design with Daphnia magna
AI summary Read the abstract
Researchers found that polystyrene nanoplastics significantly increased the toxicity of the pharmaceutical diphenhydramine to Daphnia magna water fleas at environmentally relevant concentrations. The combination caused oxidative damage that was not observed when organisms were exposed to either substance alone, indicating a synergistic interaction. The study highlights that the co-occurrence of nanoplastics and pharmaceutical pollutants in water may create compounding risks for aquatic organisms.
Influence of polystyrene nanoplastics on the toxicity of haloperidol to amphibians: An in vivo and in vitro approach
AI summary Read the abstract
Researchers investigated whether polystyrene nanoplastics change the toxicity of haloperidol, a pharmaceutical commonly found in waterways, to two species of amphibian tadpoles. They found that nanoplastics altered the drug's effects in complex ways, sometimes increasing and sometimes decreasing toxicity depending on the concentration and biological endpoint measured. The study highlights the unpredictable nature of combined pollutant exposures for amphibians already facing global population declines.
Polystyrene nanoplastics as an ecotoxicological hazard: cellular and transcriptomic evidences on marine and freshwater in vitro teleost models
AI summary Read the abstract
Researchers tested the effects of two sizes of polystyrene nanoplastics on fish cell lines from both freshwater and marine species. They found that smaller 20-nanometer particles were significantly more toxic than larger 80-nanometer ones, causing cell death through apoptosis and disrupting multiple biological pathways. The study provides evidence that nanoplastic size is a key factor in determining toxicity to aquatic organisms.
Interactive effects of micro/nanoplastics and nanomaterials/pharmaceuticals: Their ecotoxicological consequences in the aquatic systems
AI summary Read the abstract
Researchers reviewed how micro- and nanoplastics interact with co-occurring nanomaterials and pharmaceuticals in aquatic environments, finding that plastics act as vectors that can either amplify or attenuate the bioavailability and toxicity of these contaminants depending on species, trophic level, and environmental conditions.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.