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Effects of microplastics on the innate immunity and intestinal microflora of juvenile Eriocheir sinensis

The Science of The Total Environment 2019 294 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Meng Zhang, Zhiquan Liu Zhiquan Liu Zhiquan Liu Zhiquan Liu Zhiquan Liu Zhiquan Liu Zhiquan Liu Zhiquan Liu Zhiquan Liu Zhiquan Liu Donglei Wu, Ping Yu, Donglei Wu, Meng Zhang, Zhiquan Liu Meng Zhang, Meng Zhang, Zhiquan Liu Zhiquan Liu Zhiquan Liu Mingqi Cai, Mingqi Cai, Ping Yu, Ping Yu, Zhiquan Liu Zhiquan Liu Zhiquan Liu Mingqi Cai, Donglei Wu, Donglei Wu, Yunlong Zhao, Zhiquan Liu Meng Zhang, Zhiquan Liu Meng Zhang, Donglei Wu, Donglei Wu, Ping Yu, Mingqi Cai, Mingqi Cai, Donglei Wu, Ping Yu, Minghai Chen, Minghai Chen, Donglei Wu, Zhiquan Liu Zhiquan Liu Meng Zhang, Zhiquan Liu Zhiquan Liu Donglei Wu, Donglei Wu, Donglei Wu, Yunlong Zhao, Meng Zhang, Zhiquan Liu Meng Zhang, Meng Zhang, Zhiquan Liu Meng Zhang, Meng Zhang, Yunlong Zhao, Donglei Wu, Donglei Wu, Donglei Wu, Donglei Wu, Donglei Wu, Donglei Wu, Donglei Wu, Ping Yu, Mingqi Cai, Zhiquan Liu Donglei Wu, Meng Zhang, Yunlong Zhao, Yunlong Zhao, Meng Zhang, Meng Zhang, Meng Zhang, Zhiquan Liu Yunlong Zhao, Donglei Wu, Minghai Chen, Yunlong Zhao, Yunlong Zhao, Yunlong Zhao, Donglei Wu, Donglei Wu, Mingqi Cai, Zhiquan Liu Yunlong Zhao, Meng Zhang, Yunlong Zhao, Donglei Wu, Yunlong Zhao, Yunlong Zhao, Mingqi Cai, Meng Zhang, Meng Zhang, Yunlong Zhao, Yunlong Zhao, Donglei Wu, Donglei Wu, Yunlong Zhao, Yunlong Zhao, Yunlong Zhao, Yunlong Zhao, Yunlong Zhao, Yunlong Zhao, Zhiquan Liu Yunlong Zhao, Yunlong Zhao, Yunlong Zhao, Zhiquan Liu Zhiquan Liu Zhiquan Liu Meng Zhang, Zhiquan Liu Zhiquan Liu

Summary

Researchers exposed juvenile Chinese mitten crabs to different concentrations of microplastics for up to 21 days and measured immune responses and gut microbiome changes. They found that microplastic exposure disrupted immune enzyme activities and altered the composition of intestinal bacteria, with effects intensifying at higher concentrations and longer exposure times. The study suggests that microplastic pollution may compromise the immune health and gut ecology of freshwater crustaceans.

Body Systems

Hepatic Immune

The effects of microplastic exposure on the non-specific immune responses and intestinal microflora remain unclear. In this study, juveniles of the Chinese mitten crab (Eriocheir sinensis) were exposed to different concentrations of microplastics (0, 0.04, 0.4, 4, and 40 mg/L) for 7, 14, and 21 days to explore their effects. Under microplastic-induced stress, the contents or activities of most immune-related factors [haemocyanin (Hc), alkaline phosphatase (AKP), phenoloxidase (PO), lysozyme (LSZ), and acid phosphatase (ACP)] decreased after an initial increase in the low-dose or short exposure times in the haemolymph and hepatopancreas. The trends in Hc and LSZ gene expression were consistent with the corresponding changes in enzyme activities. Moreover, the haemocyte expression of caspase and MyD88 in the groups with microplastic-induced stress was higher than that in the control group, whereas the expression levels in the hepatopancreas were first increased and then decreased. Furthermore, the relative abundance of Firmicutes and Bacteroidetes decreased following exposure to 40 mg/L microplastics, whereas that of Fusobacteria and Proteobacteria increased. These results indicate that microplastics affect immune enzyme activity and immune-related gene expression and change the diversity and composition of the intestinal microflora in E. sinensis.

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