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Attenuation of Rat Colon Carcinogenesis by Styela plicata Aqueous Extract. Modulation of NF-κB Pathway and Cytoplasmic Sod1 Gene Expression

Asian Pacific Journal of Cancer Prevention 2020 3 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 30 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Elsayed I. Salim, M.M. El-Gamal, Elsayed I. Salim, M.M. El-Gamal, Mahy M. Mona, Mahy M. Mona, Hanaa Abdelhady, Hanaa Abdelhady

Summary

Researchers found that an aqueous extract from the sea squirt Styela plicata reduced colon cancer development in rats by modulating inflammatory pathways and antioxidant gene expression. This is a biomedical cancer research study unrelated to microplastics.

Body Systems

Digestive

Models

Rat

Collectively, ASCex could act as a potent chemotherapeutic drug against colon cancer, likely through the influence of its rich active metabolites which interfere with various biological pathways including inhibition of protein synthesis during cellular growth and marked induction of antioxidative capacity in the colonic mucosa. This role has been extensively discussed herein.

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