Plastic-degrading potential across the global microbiome correlates with recent pollution trends

Abstract Poor recycling has accumulated millions of tons of plastic waste in terrestrial and marine environments. While biodegradation is a plausible route towards sustainable management of plastic waste, the global diversity of plastic-degrading enzymes remains poorly understood. Taking advantage of global environmental DNA sampling projects, here we construct HMM models from experimentally-verified enzymes and mine ocean and soil metagenomes to assess the global potential of microorganisms to degrade plastics. By controlling for false positives using gut microbiome data, we compile a catalogue of over 30,000 non-redundant enzyme homologues with the potential to degrade 10 different plastic types. While differences between the ocean and soil microbiomes likely reflect the base compositions of these environments, we find that ocean enzyme abundance might increase with depth as a response to plastic pollution and not merely taxonomic composition. By obtaining further pollution measurements, we reveal that the abundance of the uncovered enzymes in both ocean and soil habitats significantly correlates with marine and country-specific plastic pollution trends. Our study thus uncovers the earth microbiome’s potential to degrade plastics, providing evidence of a measurable effect of plastic pollution on the global microbial ecology as well as a useful resource for further applied research.