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Fabrication of polyethylene terephthalate (PET) nanoparticles with fluorescent tracers for studies in mammalian cells
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Fluorescent polyethylene terephthalate (PET) nanoparticles with a hydrodynamic diameter of 158 nm were synthesized in a bottom-up approach for use as research tools. Concentration-dependent uptake and cytotoxicity were demonstrated in macrophages, providing well-characterized PET nanoplastic models for studying cellular interactions.
Fluorescent nanoparticles (NPs) comprising polyethylene terephthalate (PET) with a hydrodynamic diameter of 158 ± 2 nm were synthesized in a bottom-up approach. Concentration-dependent uptake and cytotoxicity of PET NPs in macrophages are shown. The fabrication of well-characterized NPs, derived from high-commodity polymers, will support future studies to assess effects on biological systems.
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