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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Nanoplastics Sign in to save

Do polystyrene nanoplastics aggravate the toxicity of single contaminants (okadaic acid)? Using AGS cells as a biological model

Environmental Science Nano 2021 13 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Pei‐Chun Lin, Zifan Lu, Yuanyuan Zhang, Xiuchun Liao, Lei He, Yitao Guo, Chunxia Zhou, Zhong‐Ji Qian, Pengzhi Hong, Yan‐Qiu Liang, Lei Ren, Shengli Sun, Chengyong Li

Summary

Polystyrene nanoplastics and the marine algal toxin okadaic acid were tested in combination against human gastric adenocarcinoma (AGS) cells to determine whether nanoplastics aggravate okadaic acid toxicity. PS nanoplastics enhanced toxicity by increasing reactive oxygen species production, inducing DNA damage, and impairing DNA replication and repair through the Fanconi anemia pathway.

Polymers
PS

PS and OA jointly affected cell growth and death and inhibited DNA replication and repair by increasing ROS production, resulting in DNA damage and inducing Fanconi anemia. PS aggravates the toxicity of OA to AGS cells.

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