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Do polystyrene nanoplastics aggravate the toxicity of single contaminants (okadaic acid)? Using AGS cells as a biological model
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Polystyrene nanoplastics and the marine algal toxin okadaic acid were tested in combination against human gastric adenocarcinoma (AGS) cells to determine whether nanoplastics aggravate okadaic acid toxicity. PS nanoplastics enhanced toxicity by increasing reactive oxygen species production, inducing DNA damage, and impairing DNA replication and repair through the Fanconi anemia pathway.
PS and OA jointly affected cell growth and death and inhibited DNA replication and repair by increasing ROS production, resulting in DNA damage and inducing Fanconi anemia. PS aggravates the toxicity of OA to AGS cells.
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Researchers compared how polystyrene nanoplastics and microplastics interact with the marine toxin okadaic acid in human intestinal cells. They found that nanoplastics enhanced the toxicity of okadaic acid significantly more than microplastics, triggering endoplasmic reticulum stress and cell death through calcium overload. The study suggests that smaller plastic particles may amplify the harmful effects of co-occurring environmental toxins in the digestive system.
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Researchers examined how polystyrene microplastics worsen the intestinal damage caused by okadaic acid, a common algal toxin found in seafood. Using human intestinal cells and gut bacteria experiments, they found that co-exposure disrupted the gut barrier, increased inflammation, and altered the microbial community more severely than either contaminant alone. The findings suggest that microplastics may amplify the health risks of naturally occurring marine toxins in our food supply.
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