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Dysregulation of G protein-coupled receptors in the intestine by nanoplastic exposure inCaenorhabditis elegans
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G protein-coupled receptors PAQR-2 and FSHR-1 in the intestinal barrier of the nematode C. elegans were found to regulate toxicity from nanoplastic exposure by modulating key molecular signaling pathways. Disruption of these receptors altered the nematode's response to nanoplastics, revealing a molecular mechanism by which intestinal GPCRs defend against nanoplastic damage.
GPCRs of PAQR-2 and FSHR-1 acted in the intestinal barrier to regulate nanoplastic toxicity by modulating the activities of some important molecular signaling pathways in nematodes.
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