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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Gut & Microbiome Human Health Effects Nanoplastics Policy & Risk Sign in to save

Dysregulation of G protein-coupled receptors in the intestine by nanoplastic exposure inCaenorhabditis elegans

Environmental Science Nano 2021 19 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Yunhan Yang, Qiuli Wu, Dayong Wang

Summary

G protein-coupled receptors PAQR-2 and FSHR-1 in the intestinal barrier of the nematode C. elegans were found to regulate toxicity from nanoplastic exposure by modulating key molecular signaling pathways. Disruption of these receptors altered the nematode's response to nanoplastics, revealing a molecular mechanism by which intestinal GPCRs defend against nanoplastic damage.

Models
C elegans

GPCRs of PAQR-2 and FSHR-1 acted in the intestinal barrier to regulate nanoplastic toxicity by modulating the activities of some important molecular signaling pathways in nematodes.

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