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Chronic feeding exposure to virgin and spiked microplastics disrupts essential biological functions in teleost fish

Journal of Hazardous Materials 2021 90 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Florane Le Bihanic, Jérôme Cachot, Bettie Cormier, Bettie Cormier, Bettie Cormier, Bettie Cormier, Bettie Cormier, Xavier Cousin, Florane Le Bihanic, Florane Le Bihanic, Bettie Cormier, Steffen Keiter Jérôme Cachot, Marie‐Laure Bégout, Steffen Keiter Christelle Clérandeau, Steffen Keiter Florane Le Bihanic, Florane Le Bihanic, Bettie Cormier, Steffen Keiter Steffen Keiter Jérôme Cachot, Jérôme Cachot, Jérôme Cachot, Florane Le Bihanic, Christelle Clérandeau, Jérôme Cachot, Maria Larsson, Maria Larsson, Florane Le Bihanic, Jérôme Cachot, Florane Le Bihanic, Jérôme Cachot, Bettie Cormier, Xavier Cousin, Florane Le Bihanic, Christelle Clérandeau, Jérôme Cachot, Jérôme Cachot, Christelle Clérandeau, Jérôme Cachot, Mélanie Blanc, Christelle Clérandeau, Florane Le Bihanic, Florane Le Bihanic, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Jérôme Cachot, Florane Le Bihanic, Florane Le Bihanic, Christelle Clérandeau, Christelle Clérandeau, Mathieu Cabar, Bettie Cormier, Bettie Cormier, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Florian Dubocq, Mathieu Cabar, Mélanie Blanc, Xavier Cousin, Steffen Keiter Jérôme Cachot, Maria Larsson, Maria Larsson, Jérôme Cachot, Bettie Cormier, Jean-Claude Crebassa, Jean-Claude Crebassa, Mathieu Cabar, Xavier Cousin, Maria Larsson, Xavier Cousin, Maria Larsson, Mathieu Cabar, Jean-Claude Crebassa, Jean-Claude Crebassa, Jérôme Cachot, Florane Le Bihanic, Xavier Cousin, Xavier Cousin, Florane Le Bihanic, Florane Le Bihanic, Marie‐Laure Bégout, Xavier Cousin, Xavier Cousin, Xavier Cousin, Xavier Cousin, Xavier Cousin, Xavier Cousin, Xavier Cousin, Jérôme Cachot, Steffen Keiter Mathieu Cabar, Mathieu Cabar, Steffen Keiter Christelle Clérandeau, Christelle Clérandeau, Jérôme Cachot, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Jérôme Cachot, Jérôme Cachot, Marie‐Laure Bégout, Marie‐Laure Bégout, Marie‐Laure Bégout, Marie‐Laure Bégout, Xavier Cousin, Xavier Cousin, Xavier Cousin, Steffen Keiter Steffen Keiter Steffen Keiter Steffen Keiter Steffen Keiter Mélanie Blanc, Leo W. Y. Yeung, Jean-Claude Crebassa, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Maria Larsson, Xavier Cousin, Jérôme Cachot, Jérôme Cachot, Xavier Cousin, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Christelle Clérandeau, Florian Dubocq, Xavier Cousin, Xavier Cousin, Steffen Keiter Xavier Cousin, Xavier Cousin, Xavier Cousin, Marie‐Laure Bégout, Jérôme Cachot, Marie‐Laure Bégout, Jérôme Cachot, Christelle Clérandeau, Christelle Clérandeau, Steffen Keiter Florian Dubocq, Jérôme Cachot, Florane Le Bihanic, Christelle Clérandeau, Florane Le Bihanic, Florane Le Bihanic, Christelle Clérandeau, Christelle Clérandeau, Steffen Keiter Steffen Keiter Steffen Keiter Jérôme Cachot, Jérôme Cachot, Florian Dubocq, Christelle Clérandeau, Jérôme Cachot, Jérôme Cachot, Xavier Cousin, Christelle Clérandeau, Florane Le Bihanic, Christelle Clérandeau, Christelle Clérandeau, Bettie Cormier, Christelle Clérandeau, Marie‐Laure Bégout, Bettie Cormier, Jérôme Cachot, Florane Le Bihanic, Jérôme Cachot, Xavier Cousin, Xavier Cousin, Leo W. Y. Yeung, Jérôme Cachot, Marie‐Laure Bégout, Jérôme Cachot, Jérôme Cachot, Jérôme Cachot, Jérôme Cachot, Jérôme Cachot, Jérôme Cachot, Jérôme Cachot, Jérôme Cachot, Jérôme Cachot, Florian Dubocq, Steffen Keiter Christelle Clérandeau, Jérôme Cachot, Xavier Cousin, Jérôme Cachot, Christelle Clérandeau, Jérôme Cachot, Jérôme Cachot, Steffen Keiter Steffen Keiter Steffen Keiter Jérôme Cachot, Jérôme Cachot, Florane Le Bihanic, Jérôme Cachot, Jérôme Cachot, Steffen Keiter Marie‐Laure Bégout, Jérôme Cachot, Jérôme Cachot, Jérôme Cachot, Marie‐Laure Bégout, Xavier Cousin, Xavier Cousin, Xavier Cousin, Jérôme Cachot, Xavier Cousin, Xavier Cousin, Jérôme Cachot, Jérôme Cachot, Jérôme Cachot, Florane Le Bihanic, Jérôme Cachot, Marie‐Laure Bégout, Marie‐Laure Bégout, Christelle Clérandeau, Marie‐Laure Bégout, Marie‐Laure Bégout, Marie‐Laure Bégout, Xavier Cousin, Jérôme Cachot, Jérôme Cachot, Xavier Cousin, Xavier Cousin, Bettie Cormier, Bettie Cormier, Jérôme Cachot, Xavier Cousin, Xavier Cousin, Xavier Cousin, Xavier Cousin, Marie‐Laure Bégout, Jérôme Cachot, Christelle Clérandeau, Steffen Keiter Christelle Clérandeau, Florane Le Bihanic, Jérôme Cachot, Jérôme Cachot, Christelle Clérandeau, Christelle Clérandeau, Steffen Keiter

Summary

Researchers fed zebrafish and marine medaka environmentally relevant concentrations of virgin and chemically spiked polyethylene and PVC microplastics over four months. While classical biomarkers showed no changes, significant decreases in growth and disruptions to reproduction, gut integrity, and liver function were observed. The findings suggest that chronic dietary exposure to microplastics can disrupt essential biological functions in fish even without triggering traditional toxicity markers.

Polymers

PE PVC

Body Systems

Reproductive

Models

Fish other Zebrafish

Study Type Environmental

Toxicity of polyethylene (PE) and polyvinyl chloride (PVC) microplastics (MPs), either virgin or spiked with chemicals, was evaluated in two short-lived fish using a freshwater species, zebrafish, and a marine species, marine medaka. Exposures were performed through diet using environmentally relevant concentrations of MPs over 4 months. No modification of classical biomarkers, lipid peroxidation, genotoxicity or F0 behaviour was observed. A significant decrease in growth was reported after at least two months of exposure. This decrease was similar between species, independent from the type of MPs polymer and the presence or not of spiked chemicals, but was much stronger in females. The reproduction was evaluated and it revealed a significant decrease in the reproductive output for both species and in far more serious numbers in medaka. PVC appeared more reprotoxic than PE as were MPs spiked with PFOS and benzophenone-3 compared to MPs spiked with benzo[a]pyrene. Further, PVC-benzophenone-3 produced behavioural disruption in offspring larvae. These results obtained with two species representing different aquatic environments suggest that microplastics exert toxic effects, slightly different according to polymers and the presence or not of sorbed chemicals, which may lead in all cases to serious ecological disruptions.

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