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Integrative Analysis of Pharmacology and Transcriptomics Predicts Resveratrol Will Ameliorate Microplastics-Induced Lung Damage by Targeting Ccl2 and Esr1
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Researchers used pharmacology network analysis and transcriptomics to predict that resveratrol may help mitigate lung damage caused by microplastic exposure. They identified two key molecular targets, Ccl2 and Esr1, through which resveratrol could exert protective effects. The study offers a new perspective on potential approaches to addressing microplastic-induced lung injury, though further experimental validation is needed.
This study demonstrated that RES may mitigate lung injury induced by MPs by targeting Esr1 and Ccl2. Our research offers a novel perspective on the prevention and treatment of MPs-induced lung injury.
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Microplastic exposure and allergic rhinitis: Network toxicology, and molecular docking insights
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Researchers used network toxicology and molecular docking approaches to investigate how microplastic exposure may contribute to allergic rhinitis. The study identified key molecular mediators through which microplastics may drive respiratory inflammation pathways, and found that resveratrol could potentially modulate these pathways, offering insights into the mechanisms linking microplastic exposure to allergic respiratory conditions.
Resveratrol in Microplastic‐ and Nanoplastic‐Induced Toxicity: Current Evidence, Mechanistic Insights, and Future Directions
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This review paper summarizes existing research on how tiny plastic particles called microplastics and nanoplastics may harm cells, and how resveratrol, a plant compound found in grapes and berries, might affect related cell signaling pathways. The authors note that this evidence comes only from a small number of lab studies in animals or cells, with no human studies, so the proposed effects remain unconfirmed.
Avaliação do efeito de citotoxicidade dos microplásticos na linhagem mamária humana MCF10A
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Researchers assessed the cytotoxicity of microplastics on the non-tumoral human breast cell line MCF10A and explored whether the antioxidant resveratrol could mitigate those effects. The study found that microplastics negatively impacted cell viability and that resveratrol showed potential as a protective agent in the cellular context of MP exposure.
Assessing the toxicological effects of exposure to environmental pollutants PET-MPs on vascular diseases: insights from network toxicology, molecular docking, molecular dynamics, and experimental validation
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Researchers used network toxicology, molecular docking, and cell experiments to investigate how PET microplastics may contribute to vascular diseases. They identified four core molecular targets and found that PET microplastics induced mitochondrial oxidative stress, increased reactive oxygen species, and promoted vascular smooth muscle cell death. The study provides initial molecular-level evidence that microplastic exposure may be a contributing factor in vascular damage and remodeling.
Intersection of microplastic toxicity targets and differentially expressed genes in allergic rhinitis.
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Network analysis identified a set of genes that are both targeted by common microplastics (PE, PP, PVC, PS) and differentially expressed in allergic rhinitis, providing a molecular framework for investigating how microplastic exposure may contribute to nasal allergy pathogenesis.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.