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Gut & Microbiome
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In vitro models of gut digestion across childhood: current developments, challenges and future trends
Biotechnology Advances2021
28 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 50
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
Charlène Roussel,
Muriel Mercier‐Bonin
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Muriel Mercier‐Bonin
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Muriel Mercier‐Bonin
Muriel Mercier‐Bonin
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Muriel Mercier‐Bonin
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin
Lucie Etienne‐Mesmin,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Charlène Roussel,
Alessandra Dominicis,
Alessandra Dominicis,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin
E Fournier,
Delphine Ley,
Stéphanie Blanquet‐Diot,
Lucie Etienne‐Mesmin,
Muriel Mercier‐Bonin
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin
Marie‐Agnès Peyron,
Lucie Etienne‐Mesmin,
Charlène Roussel,
Charlène Roussel,
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin
Valérie Collado,
Muriel Mercier‐Bonin
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin
Muriel Mercier‐Bonin
Muriel Mercier‐Bonin
Muriel Mercier‐Bonin
Christophe Lacroix,
Stéphanie Blanquet‐Diot,
Tom Van de Wiele,
Tom Van de Wiele,
Lucie Etienne‐Mesmin,
Muriel Mercier‐Bonin
Muriel Mercier‐Bonin
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Monique Alric,
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Monique Alric,
Muriel Mercier‐Bonin
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Tom Van de Wiele,
Christophe Lacroix,
Lucie Etienne‐Mesmin,
Christophe Chassard,
Lucie Etienne‐Mesmin,
Stéphanie Blanquet‐Diot,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin
Muriel Mercier‐Bonin
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin
Muriel Mercier‐Bonin
Muriel Mercier‐Bonin
Muriel Mercier‐Bonin
Summary
Researchers review the development of in vitro gut digestion models for children from birth to age three, summarizing how gut anatomy, physiology, and microbiota evolve during this period and how existing static and dynamic model systems can simulate these compartments to study nutrition, drug delivery, and environmental contaminant exposure.
The human digestion is a multi-step and multi-compartment process essential for human health, at the heart of many issues raised by academics, the medical world and industrials from the food, nutrition and pharma fields. In the first years of life, major dietary changes occur and are concomitant with an evolution of the whole child digestive tract anatomy and physiology, including colonization of gut microbiota. All these phenomena are influenced by child exposure to environmental compounds, such as drugs (especially antibiotics) and food pollutants, but also childhood infections. Due to obvious ethical, regulatory and technical limitations, in vivo approaches in animal and human are more and more restricted to favor complementary in vitro approaches. This review summarizes current knowledge on the evolution of child gut physiology from birth to 3 years old regarding physicochemical, mechanical and microbial parameters. Then, all the available in vitro models of the child digestive tract are described, ranging from the simplest static mono-compartmental systems to the most sophisticated dynamic and multi-compartmental models, and mimicking from the oral phase to the colon compartment. Lastly, we detail the main applications of child gut models in nutritional, pharmaceutical and microbiological studies and discuss the limitations and challenges facing this field of research.