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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Nanoplastics Reproductive & Development Sign in to save

Multi-omics analysis of testis after long-term exposure to polystyrene nanoplastics reveals premature testicular aging and age-dependent damage in mice

Particle and Fibre Toxicology 2025 2 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Hongrui Feng, Yuji Huang, Yuji Huang, Hanbin Zhang, Zhiming Li, Xixian Cen, Yuge Zhuang, Xiaoyuan Zhang, Ke Ma, Shipeng Ruan, Runduan Yi, Zicong Huang, Wenyuan Liu, Maoyong Song, Zhenlie Huang, Zhenguo Chen

Summary

Researchers used multi-omics analysis to study the effects of long-term polystyrene nanoplastic exposure on mouse testes and found signs of premature testicular aging. The damage was dependent on both the age of the mice and the duration of exposure, with younger animals showing particular vulnerability. The study suggests that protecting mRNA metabolism and testosterone production could help preserve reproductive function in males exposed to nanoplastics.

Polymers
PS
Body Systems
Reproductive
Models
Mouse

Integrated with multi-omics analyses, our study collectively extends the current understanding of PS-NP-induced testicular and sperm toxicology, highlighting age- and duration-dependent risks to male reproduction. Protecting mRNA metabolism and testosterone production may help preserve reproductive capacity in young males exposed to NPs.

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