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Cyanidin-3-O-glucoside reduces nanopolystyrene-induced toxicity and accumulation: roles of mitochondrial energy metabolism and cellular efflux
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Cyanidin-3-O-glucoside, a plant pigment, reduced the toxicity and cellular accumulation of polystyrene nanoplastics in model organisms by enhancing mitochondrial energy metabolism and boosting the activity of ABC transporter proteins that export nanoplastics from cells.
C3G reduces polystyrene nanoplastic toxicity to different models, by which C3G-mediated energy metabolism improved the activity of ABC transporters and cellular efflux of polystyrene.
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Canidin-3-glucoside prevents nano-plastics induced toxicity via activating autophagy and promoting discharge
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Researchers showed that cyanidin-3-glucoside (C3G), a natural anthocyanin, reduced polystyrene nanoplastic toxicity in Caco-2 cells and C. elegans by activating autophagy and promoting cellular discharge of internalized particles, suggesting a dietary protective mechanism.
Cyanidin-3-O-glucoside impacts fecal discharge of polystyrene microplastics in mice: Potential role of microbiota-derived metabolites
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Researchers found that the dietary compound cyanidin-3-O-glucoside accelerated the fecal discharge of polystyrene microplastics in mice by remodeling gut microbiota composition and altering microbiota-derived metabolites, suggesting a potential dietary strategy for reducing microplastic accumulation.
Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice
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In mice exposed to polystyrene microplastics, cyanidin-3-O-glucoside (C3G), an anthocyanin found in many fruits, was given as a supplement. Mice that received C3G had less polystyrene in tissue, more in feces, and lower oxidative stress and inflammation. C3G also shifted gut bacteria linked to inflammation.
Toxicological effects and molecular metabolic of polystyrene nanoplastics on soybean (Glycine max L.): Strengthening defense ability by enhancing secondary metabolisms
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Researchers exposed soybean seedlings to polystyrene nanoplastics and found that the tiny particles were absorbed by the roots and transported throughout the plant. The nanoplastics caused oxidative stress and slowed growth, though the plants activated defense mechanisms through secondary metabolism. This is concerning because crops that absorb nanoplastics could transfer them to humans through the food supply.
Uptake of nanopolystyrene particles induces distinct metabolic profiles and toxic effects in Caenorhabditis elegans
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Researchers exposed the nematode C. elegans to 50 nm and 200 nm nanopolystyrene particles and used metabolomics to show that particles disrupt energy metabolism — reducing TCA cycle intermediates and altering glucose and lactate — while also decreasing locomotion, reproduction, and inducing oxidative stress.
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