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Human Health Effects
Nanoplastics
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Polystyrene nanoplastics affect the human ubiquitin structure and ubiquitination in cells: a high-resolution study
Chemical Science2022
17 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 45
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Mariacristina Cocca,
Mariacristina Cocca,
Maria della Valle,
Mariacristina Cocca,
Mariacristina Cocca,
Mariacristina Cocca,
Rachele Castaldo,
Mariacristina Cocca,
Mariacristina Cocca,
Mariacristina Cocca,
Mariacristina Cocca,
Gennaro Gentile,
Roberto Avolio,
Roberto Avolio,
Roberto Avolio,
Roberto Avolio,
Roberto Avolio,
Roberto Avolio,
Gianluca D’Abrosca,
Mariacristina Cocca,
Rachele Castaldo,
Mariacristina Cocca,
Mariacristina Cocca,
Mariacristina Cocca,
Mariacristina Cocca,
Maria Emanuela Errico,
Maria Emanuela Errico,
Mariacristina Cocca,
Mariacristina Cocca,
Maria Emanuela Errico,
Maria Emanuela Errico,
Maria Teresa Gentile,
Mariacristina Cocca,
Mariacristina Cocca,
Roberto Avolio,
Roberto Avolio,
Roberto Avolio,
Roberto Avolio,
Roberto Avolio,
Gennaro Gentile,
Gennaro Gentile,
Gennaro Gentile,
Gennaro Gentile,
Gennaro Gentile,
Gennaro Gentile,
Mariacristina Cocca,
Rachele Castaldo,
Mariacristina Cocca,
Rachele Castaldo,
Mariacristina Cocca,
Rachele Castaldo,
Rachele Castaldo,
Mariacristina Cocca,
Roberto Avolio,
Mariacristina Cocca,
Mariacristina Cocca,
Mariacristina Cocca,
Gennaro Gentile,
Rachele Castaldo,
Gennaro Gentile,
Gennaro Gentile,
Rachele Castaldo,
Mariacristina Cocca,
Gennaro Gentile,
Gennaro Gentile,
Mariacristina Cocca,
Rachele Castaldo,
Rachele Castaldo,
Gennaro Gentile,
Mariacristina Cocca,
Maria Emanuela Errico,
Maria Emanuela Errico,
L. Russo,
Maria Emanuela Errico,
Roberto Avolio,
Mariacristina Cocca,
Mariacristina Cocca,
Maria Emanuela Errico,
Maria Emanuela Errico,
Roberto Avolio,
Roberto Avolio,
Roberto Avolio,
Maria Emanuela Errico,
Gennaro Gentile,
Mariacristina Cocca,
Roberto Avolio,
Rachele Castaldo,
Maria Emanuela Errico,
Maria Emanuela Errico,
Mariacristina Cocca,
Carla Isernia,
Mariacristina Cocca,
Maria Emanuela Errico,
Mariacristina Cocca,
Maria Emanuela Errico,
Maria Emanuela Errico,
Maria della Valle,
Mariacristina Cocca,
Mariacristina Cocca,
Maria Emanuela Errico,
Maria Emanuela Errico,
Mariacristina Cocca,
Mariacristina Cocca,
Rachele Castaldo,
Rachele Castaldo,
Rachele Castaldo,
Rachele Castaldo,
Gennaro Gentile,
Roberto Avolio,
Roberto Avolio,
Mariacristina Cocca,
Maria Emanuela Errico,
Maria Emanuela Errico,
Rachele Castaldo,
S. Di Gaetano,
Gennaro Gentile,
Mariacristina Cocca,
Mariacristina Cocca,
Gennaro Gentile,
Gennaro Gentile,
Gennaro Gentile,
Mariacristina Cocca,
Maria Emanuela Errico,
Gennaro Gentile,
Mariacristina Cocca,
Maria Emanuela Errico,
Rachele Castaldo,
S. Di Gaetano,
Roberto Avolio,
Maria Emanuela Errico,
Rachele Castaldo,
Gianluca D’Abrosca,
Rachele Castaldo,
Gennaro Gentile,
Mariacristina Cocca,
Mariacristina Cocca,
Maria della Valle,
Mariacristina Cocca,
Gennaro Gentile,
Mariacristina Cocca,
Roberto Avolio,
Gennaro Gentile,
Gennaro Gentile,
Mariacristina Cocca,
Mariacristina Cocca,
Mariacristina Cocca,
Rachele Castaldo,
Mariacristina Cocca,
Mariacristina Cocca,
Mariacristina Cocca,
Maria Emanuela Errico,
Mariacristina Cocca,
Maria Emanuela Errico,
Mariacristina Cocca,
Maria Emanuela Errico,
Mariacristina Cocca,
Mariacristina Cocca,
Mariacristina Cocca,
Mariacristina Cocca,
Gennaro Gentile,
Mariacristina Cocca,
Gennaro Gentile,
Mariacristina Cocca,
Mariacristina Cocca,
Maria Teresa Gentile,
Carla Isernia,
Mariacristina Cocca,
Mariacristina Cocca,
Mariacristina Cocca,
Gaetano Malgieri
Roberto Fattorusso,
Maria Emanuela Errico,
Maria Teresa Gentile,
Mariacristina Cocca,
Roberto Fattorusso,
Mariacristina Cocca,
Rachele Castaldo,
Mariacristina Cocca,
Gaetano Malgieri
Mariacristina Cocca,
Carla Isernia,
Roberto Fattorusso,
Maria Emanuela Errico,
Gaetano Malgieri
Summary
Using NMR and TEM analyses, polystyrene nanoplastics were shown to form a hard protein corona with human ubiquitin and to impair ubiquitination in HeLa cells, revealing a potential mechanism by which nanoplastic exposure disrupts protein degradation pathways in human cells.
Humans are estimated to consume several grams per week of nanoplastics (NPs) through exposure to a variety of contamination sources. Nonetheless, the effects of these polymeric particles on living systems are still mostly unknown. Here, by means of CD, NMR and TEM analyses, we describe at an atomic resolution the interaction of ubiquitin with polystyrene NPs (PS-NPs), showing how a hard protein corona is formed. Moreover, we report that in human HeLa cells exposure to PS-NPs leads to a sensible reduction of ubiquitination. Our study overall indicates that PS-NPs cause significant structural effects on ubiquitin, thereby influencing one of the key metabolic processes at the base of cell viability.