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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Detection Methods Environmental Sources Human Health Effects Nanoplastics Sign in to save

Nanomechanical Atomic Force Microscopy to Probe Cellular Microplastics Uptake and Distribution

International Journal of Molecular Sciences 2022 63 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Farida Akhatova, Rawil Fakhrullin Ilnur Ishmukhametov, Ilnur Ishmukhametov, Ilnur Ishmukhametov, Ilnur Ishmukhametov, Farida Akhatova, Farida Akhatova, Ilnur Ishmukhametov, Farida Akhatova, Ilnur Ishmukhametov, Farida Akhatova, Farida Akhatova, Rawil Fakhrullin Rawil Fakhrullin Gӧlnur Fakhrullina, Gӧlnur Fakhrullina, Rawil Fakhrullin Gӧlnur Fakhrullina, Rawil Fakhrullin Rawil Fakhrullin Rawil Fakhrullin Rawil Fakhrullin Rawil Fakhrullin Rawil Fakhrullin Rawil Fakhrullin Rawil Fakhrullin

Summary

Researchers used atomic force microscopy in a specialized nanomechanical mode to visualize how human skin cells take up and distribute polystyrene microplastics. They were able to distinguish between particles attached to the cell surface and those internalized within the cell, detecting particles as small as 500 nanometers. The study demonstrates a powerful new technique for studying how plastic particles interact with human cells at the nanoscale.

Polymers
PS
Body Systems
Integumentary
Study Type In vitro

The concerns regarding microplastics and nanoplastics pollution stimulate studies on the uptake and biodistribution of these emerging pollutants in vitro. Atomic force microscopy in nanomechanical PeakForce Tapping mode was used here to visualise the uptake and distribution of polystyrene spherical microplastics in human skin fibroblast. Particles down to 500 nm were imaged in whole fixed cells, the nanomechanical characterization allowed for differentiation between internalized and surface attached plastics. This study opens new avenues in microplastics toxicity research.

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