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ox-LDL-Induced Endothelial Progenitor Cell Oxidative Stress via p38/Keap1/Nrf2 Pathway
Summary
Researchers investigated the molecular pathway by which oxidized low-density lipoprotein induces oxidative stress in endothelial progenitor cells, identifying the p38/Keap1/Nrf2 signaling cascade as the key mechanism. They found that ox-LDL activation of this pathway resulted in endothelial progenitor cell dysfunction and apoptosis, implicating this pathway in cardiovascular disease progression.
ox-LDL activated EPCs p38/Keap1/Nrf2 pathway and induced oxidative stress, dysfunction, and apoptosis of EPCs.
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