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OX-LDL promotes insufficient autophagy and apoptosis of ovarian granulosa cells through regulation ROS-mediated PI3K/Akt/mTOR pathway
Summary
This study investigated how oxidized low-density lipoprotein (OX-LDL) triggers cell death in ovarian granulosa cells through oxidative stress pathways. The research identified specific molecular signaling cascades involved in follicle cell damage. While not directly about microplastics, oxidative stress pathways of the type studied here are also activated by microplastic exposure, making this relevant to understanding plastic-related reproductive health risks.
The purpose of this study was to determine the role of Oxidized Low Density Lipoprotein (OX LDL) promotes insufficient autophagy and apoptosis of ovarian granulosa cells through regulation Reactive Oxygen Species (ROS) mediated PI3K Akt/mTOR pathway.
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