We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Effect of Microplastics on Nasal and Intestinal Microbiota of High-Exposure Population: Protocol for an Observational Cross-sectional Study
AI summary Read the abstract
This study protocol describes a planned investigation comparing the nasal and gut bacteria of 60 plastic factory workers with 60 people in cleaner environments. Animal studies have shown that long-term microplastic exposure can alter the body's microbial communities, potentially leading to respiratory, digestive, and immune problems. This will be one of the first studies to look at how real-world microplastic exposure affects the human microbiome.
Abstract Background: Microplastics have the characteristics of small size, high specific area, strong ability to adsorb pollutants, and difficult to degrade. They have become a major global environmental problem that humans urgently need to address. A balanced micro-ecosystem is essential to human health. Animal studies have shown that long-term exposure to microplastics can change the characteristics of the microbiota in organisms, leading to respiratory, digestive, immune and other system diseases. However, the current research on microplastics is still dominated by animal experiments, and the impact of microplastics on human health is still in its infancy, so relevant research is urgently needed. Methods/Design: Sixty participants with high exposure to microplastics will come from a plastic factory in Chengdu, China. We will conduct 16S rRNA sequencing and 8700 LDIR laser infrared imaging to the samples from the participants and from the environment. We will evaluate the health status of the participants through Short-Form Health Survey 36 (SF-36). For comparison, we will also collect samples and questionnaires from 60 volunteers from an area with good environmental quality in Chengdu. To find out the potential predictors and to access the difference between the groups, statistical analysis will be performed in the end. Discussion: The study will be the first observational cross-sectional study focusing on the effects of microplastics on nasal and intestinal microbiota of high-exposure population. The study is expected to provide reliable evidence to fill the gaps in the impact of microplastics on human health. Trial registration: This trial was registered with Chinese Clinical Trial Registry (ChiCTR2100049480) on August 2, 2021.
More Papers Like This
Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study
AI summary Read the abstract
This study protocol describes a cross-sectional observational study designed to examine the effects of microplastic exposure on nasal and gut microbiota in plastic factory workers in Chengdu, China. The research will compare microbiota samples from 20 high-exposure workers to 20 controls from areas with good environmental quality, aiming to provide the first human evidence on how occupational microplastic exposure affects the body's microbial communities.
Effect of microplastics on nasal and intestinal microbiota of the high-exposure population
AI summary Read the abstract
This study investigated the effects of microplastic exposure on the nasal and intestinal microbiota of highly exposed human populations. The research aimed to understand how microplastic contamination may alter the microbial communities in key areas of the human body.
Impact of microplastics on human gut microbiota: first evidences from in vitro gut models
AI summary Read the abstract
Researchers investigated the impact of microplastics on human gut microbiota using in vitro gut models, providing early experimental evidence of how microplastic exposure may disrupt intestinal microbial communities. The study offers foundational data on microplastic-microbiome interactions that are difficult to study directly in humans.
Impact of microplastics on the intestinal microbiota: A systematic review of preclinical evidence
AI summary Read the abstract
Across 28 preclinical studies, microplastics triggered intestinal dysbiosis characterized by increased Firmicutes and Proteobacteria and decreased Bacteroidetes, while increasing gut permeability and elevating pro-inflammatory cytokines including IL-1β, TNF-α, and IL-6.
Gut microbiome remodeling induced by microplastic exposure in humans
AI summary Read the abstract
This review synthesizes evidence on how microplastic exposure affects the human gut microbiome, drawing on cross-sectional studies of people exposed through plastic food containers and other sources. Evidence indicates that microplastic exposure is associated with shifts in gut bacteria composition, including increases in certain bacterial groups linked to inflammation. The authors explore potential connections between microplastic-induced changes in gut bacteria and the development of various health conditions.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.