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Determination of acute toxicity of sodium pyrithione on common carp and its effects on some hormones and hematological parameters
Summary
Researchers determined the 96-hour LC50 of sodium pyrithione for common carp (Cyprinus carpio) at 102.76 micrograms/L and assessed sub-lethal effects on hematological parameters and hormones, finding decreased red blood cell counts, hemoglobin, hematocrit, white blood cell counts, and lymphocytes alongside reduced growth hormone and IGF-1 levels. The study demonstrates endocrine and hematological disruption from this antimicrobial compound used in aquatic environments.
Abstract In this study, the LC 50 -24 h value of sodium pyrithione (NaPT) on Cyprinus carpio was determined 102.7643 µg/L. The effects of NaPT exposure on hematological parameters and some hormones in carp were also studied. In the groups exposed to NaPT compared to the control group, there was a decrease in the erythrocyte count (RBC), hemoglobin (Hb), hematocrit (Hct) values, total leukocyte count (WBC), lymphocyte and monocyte ratios, while an increased ratio was observed in granulocyte. Hormone analysis revealed a decrease in serum growth hormone (GH), insulin-like growth factor-1 (IGF-1), Thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) levels, while an increase was observed in total triiodothyronine (TT3), total thyroxine (TT4), adrenocorticotropic hormone (ACTH) and cortisol levels. Depending on the duration of exposure, a decrease was observed in the ratios of RBC, Hb, Hct, WBC, lymphocytes, monocytes, GH, IGF-1, TSH, TT3, and TT4 in both dose groups, while a decrease was observed in FT3 levels in the NaPT-20 dose group. ACTH and cortisol levels were increased in both dose groups depending on the duration of exposure. At the FT4 level, it was determined that there was no statistically significant difference in the comparison between the exposure duration.
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