Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Sign in to save

Intergenerational and biological effects of roxithromycin and polystyrene microplastics to Daphnia magna

Aquatic Toxicology 2022 40 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Zhenhua Yan Zhenhua Yan Haohan Yang, Haohan Yang, Zhenhua Yan Haohan Yang, Zhenhua Yan Zhenhua Yan Jiaqiang Liu, Zhenhua Yan Jiaqiang Liu, Zhenhua Yan Zhenhua Yan Haohan Yang, Jiaqiang Liu, Haohan Yang, Haohan Yang, Haohan Yang, Haohan Yang, Qiyan Feng, Qiyan Feng, Zhenhua Yan Zhenhua Yan Haohan Yang, Haohan Yang, Zhenhua Yan Zhenhua Yan Jianchao Liu, Zhenhua Yan Zhenhua Yan Jiaqiang Liu, Qiyan Feng, Qiyan Feng, Haohan Yang, Haohan Yang, Haohan Yang, Zhenhua Yan Qingjun Meng, Zhenhua Yan Haohan Yang, Jiaqiang Liu, Haohan Yang, Haohan Yang, Zhenhua Yan Zhenhua Yan Zhenhua Yan Jianchao Liu, Zhenhua Yan Zhenhua Yan Zhenhua Yan Jiaqiang Liu, Zhenhua Yan Jiaqiang Liu, Qiyan Feng, Qiyan Feng, Zhenhua Yan Zhenhua Yan Jianchao Liu, Jianchao Liu, Zhenhua Yan Jianchao Liu, Jianchao Liu, Jianchao Liu, Jianchao Liu, Jiaqiang Liu, Jianchao Liu, Zhenhua Yan Zhenhua Yan Jianchao Liu, Zhenhua Yan Zhenhua Yan Zhenhua Yan Jianchao Liu, Jianchao Liu, Zhenhua Yan Jianchao Liu, Jiaqiang Liu, Zhigang Liu, Jiaqiang Liu, Zhengxie Zhou, Jiaqiang Liu, Zhengxie Zhou, Zhenhua Yan

Summary

Researchers studied the intergenerational effects of the antibiotic roxithromycin combined with polystyrene microplastics on water fleas (Daphnia magna) across multiple generations. They found that UV-aged microplastics altered the carrier effects on the antibiotic compared to pristine particles, changing survival and reproductive outcomes. The study suggests that the aging and weathering state of microplastics in the environment influences how they interact with pharmaceutical pollutants and their combined toxicity.

Polymers

Body Systems

Reproductive

Models

Daphnia

The influence of microplastics (MPs) on transgenerational effects of pharmaceuticals are drawing growing attention, however, whether aged process will alter the carrier effects of MPs were unknown. In this study, the intergenerational toxicity of single and combined exposure of polystyrene microplastics (PS-MPs) and roxithromycin (ROX) were investigated at the environmentally related concentrations, using Daphina magna as test organism. In the presence of UV-aged PS-MPs, the survival of D. magna for maternal generation (F0) at ROX concentration of 0.1 and 10 µg/L were increased by 20% and 40%, respectively. Meanwhile, the inhibition effects of ROX on the number of offspring and intrinsic rate of natural increase were obviously moderated. All these reproductive toxicity of ROX and PS-MPs in the first offspring (F1) were further aggravated both for the single and combined exposure. And the adverse effects disappeared much easier for the single exposure compared to the co-exposure through subsequent recovery. The combined exposure resulted in the change of inhibition of ROX on the swimming velocity and acceleration of D. magna into induction, while the feeding behavior kept inhibited. The AChE activity was distinctly increased by 1.61-3.25 times for the single and combined treatments, and the induction level of UV-aged MPs was higher than that of original MPs. Oxidative stress of the single exposure of ROX and original PS-MPs was observed with obvious induction of T-AOC and SOD activity, while the significant increase of MDA content was observed for the co-exposure. Among all indicators, the biochemical biomarkers and time of first brood were attributed to a class among all indicators, indicating that the time of first brood might be the most sensitive reproductive toxicity index. These results illustrated that both maternal impacts and offspring quality need to be considered for assessment of interaction of emerging contaminants.

Read via DOI PubMed

Share this paper

Post Share Share Pin Email