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Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Human Health Effects
Marine & Wildlife
Nanoplastics
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Early molecular responses of mangrove oysters to nanoplastics using a microfluidic device to mimic environmental exposure
Journal of Hazardous Materials2022
14 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 45
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Researchers used a microfluidic chip mimicking estuarine water conditions to expose mangrove oysters to nanoplastics from polystyrene and beach-collected sources, finding that low concentrations of beach-derived nanoplastics triggered the strongest gene expression responses. Genes involved in endocytosis, oxidative stress, and DNA repair were activated, demonstrating the utility of microfluidic devices for nanoplastic ecotoxicology.
This study assessed the effects of nanoplastics (NPs) using for the very first time microfluidic devices (chip) mimicking transition waters. Three kinds of NPs were tested: crushed NPs from polystyrene pellets (NP-PS), or from Guadeloupe beaches (NP-G); and latex PS (PSL-COOH). The eluted fractions from the microfluidic device showed a low aggregation of NPs. They remained stable over time in the exposure media, with a stabilization of NPs of small sizes (< 500 nm). These chips were thus used for the toxicological assessment of NPs on swamp oysters, Isognomon alatus. Oysters were exposed for 7 days to the chip elution fraction of either NP-G, NP-PS or PSL-COOH (0.34-333 µg.L). Gene transcription analyses showed that the tested NPs triggered responses on genes involved in endocytosis, mitochondrial metabolism disruption, oxidative stress, DNA repair, and detoxification. Highest responses were observed after NP-G exposure at low concentrations (1 µg.L), as they are originated from the natural environment and accumulated contaminants, enhancing toxicological effects. As salinity influences aggregation and then the bioavailability of NPs, our results demonstrated the importance of using microfluidic devices for ecotoxicological studies on swamp or estuarine species.