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Effects of Aroclor 1254 on Intestinal Immunity, Metabolism, and Microflora in Zebrafish

Frontiers in Nutrition 2022 10 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 45 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Qing-Lang Song, Di-Hua Zhu, Qing-Lang Song, Qing-Lang Song, Di-Hua Zhu, Yao Hu, Qing-Lang Song, Qing-Lang Song, Qing-Lang Song, Yao Hu, Wan Wei, Fang‐Hong Nie, Fang‐Hong Nie, Fang‐Hong Nie, Fang‐Hong Nie, Fang‐Hong Nie, Fang‐Hong Nie, Fang‐Hong Nie, Fang‐Hong Nie, Fang‐Hong Nie, Wan Wei, Fang‐Hong Nie, Jinjun Chen Fang‐Hong Nie, Fang‐Hong Nie, Di-Hua Zhu, Di-Hua Zhu, Yao Hu, Yao Hu, Min Zhang, Min Zhang, Di-Hua Zhu, Di-Hua Zhu, Di-Hua Zhu, Jinjun Chen Qing-Lang Song, Wan Wei, Di-Hua Zhu, Wan Wei, Qing-Lang Song, Qing-Lang Song, Qing-Lang Song, Yao Hu, Yao Hu, Yao Hu, Wan Wei, Yao Hu, Wan Wei, Yao Hu, Yao Hu, Yao Hu, Yao Hu, Qing-Lang Song, Danju Kang, Danju Kang, Danju Kang, Qing-Lang Song, Danju Kang, Danju Kang, Danju Kang, Danju Kang, Danju Kang, Wan Wei, Danju Kang, Danju Kang, Hong‐Ying Lin, Zhibao Chen, Wan Wei, Hong‐Ying Lin, Hong‐Ying Lin, Zhibao Chen, Danju Kang, Hong‐Ying Lin, Zhibao Chen, Danju Kang, Zhibao Chen, Zhibao Chen, Hong‐Ying Lin, Hong‐Ying Lin, Hong‐Ying Lin, Jinjun Chen Hong‐Ying Lin, Hong‐Ying Lin, Hong‐Ying Lin, Hong‐Ying Lin, Jinjun Chen Hong‐Ying Lin, Jinjun Chen Jinjun Chen Jinjun Chen

Summary

Zebrafish exposed to the PCB mixture Aroclor 1254 for 21 days at concentrations of 5-15 micrograms per liter showed intestinal inflammation, oxidative stress, gut microbiome disruption, and altered metabolomics profiles in a dose-dependent manner. The results demonstrate that PCBs impair intestinal barrier function and gut health, potentially contributing to systemic toxicity through increased gut permeability.

Body Systems

Immune

Models

Zebrafish

Polychlorinated biphenyls (PCBs) are widely distributed environmental toxicants, whose biological toxicity is magnified step by step through the transmission of the food chain. However, there is little research about the effect of PCBs on intestinal epithelial barrier function. In this experiment, the effects of PCB exposure on the intestines of zebrafish were evaluated. Animals were exposed to Aroclor 1254 (5 μg/L, 10 μg/L, 15 μg/L). After 21 days, the changes in histology, enzyme biomarkers, intestinal microorganisms, and metabolomics were detected. The inflammation and oxidative stress in the intestines of zebrafish were observed. Additionally, there were significant changes in intestinal microbiota and tissue metabolism, most of which were associated with oxidative stress, inflammation, and lipid metabolism. The results showed that PCBs exposure resulted in intestinal inflammation and oxidative stress in zebrafish.Moreover, intestinal metabolites and intestinal microflora of zebrafish were also disturbed. This study verified that exposure can lead to intestinal damage and changes in intestinal metabolic capacity and microorganisms, enlightening the consequences of PCB exposure.

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