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Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Gut & Microbiome
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Changes of physico-chemical properties of nano-biomaterials by digestion fluids affect the physiological properties of epithelial intestinal cells and barrier models
Particle and Fibre Toxicology2022
28 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 40
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Giulia Antonello,
Marie Carrière,
Francesco Barbero,
Enrico Bergamaschi,
Arianna Marucco,
Francesco Barbero,
Francesco Barbero,
Francesco Barbero,
Francesco Barbero,
Francesco Barbero,
Elena Gazzano,
Francesco Barbero,
Francesco Barbero,
Panagiotis Kainourgios,
Enrico Bergamaschi,
Marie Carrière,
Francesco Barbero,
Francesco Barbero,
Francesco Barbero,
Marco P. Monopoli
Marco P. Monopoli
Ivana Fenoglio,
Ivana Fenoglio,
Francesco Barbero,
Costanza Ravagli,
Francesco Barbero,
Francesco Barbero,
Ana González-Paredes,
Marie Carrière,
Costas A. Charitidis,
Marie Carrière,
Francesco Barbero,
Marie Carrière,
Costas A. Charitidis,
Simone Sprio,
Esperanza Padín-González,
Marie Carrière,
Marie Carrière,
Ivana Fenoglio,
Ivana Fenoglio,
Marie Carrière,
Mahmoud G. Soliman,
Francesco Barbero,
David Béal,
Francesco Barbero,
Enrico Bergamaschi,
Ivana Fenoglio,
Ivana Fenoglio,
Ivana Fenoglio,
Ivana Fenoglio,
Ivana Fenoglio,
Ivana Fenoglio,
Francesco Barbero,
Ivana Fenoglio,
Costas A. Charitidis,
Ivana Fenoglio,
Paolo Gasco,
Giovanni Baldi,
Panagiotis Kainourgios,
Marie Carrière,
Marie Carrière,
Marco P. Monopoli
Ivana Fenoglio,
Costas A. Charitidis,
Francesco Barbero,
Enrico Bergamaschi,
Ivana Fenoglio,
Ivana Fenoglio,
Chiara Riganti,
Enrico Bergamaschi,
Enrico Bergamaschi,
Marco P. Monopoli
Summary
Researchers found that when nano-sized biomaterials pass through simulated digestive fluids, their physical and chemical properties change in ways that affect how intestinal cells respond to them. This highlights the importance of testing ingested nanoparticles — including nanoplastics — through realistic digestion conditions before drawing conclusions about their safety.
Overall, the results add a piece of evidence on the importance of applying validated in vitro SHDS models for the assessment of NBM intestinal toxicity/biocompatibility. We propose the association of chemical and microscopic characterization, SHDS and in vitro tests on both immortalised and primary cells as a robust screening pipeline useful to monitor the changes in the physico-chemical properties of ingested NBMs and their effects on intestinal cells.