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Size dependent nephrotoxicity of polystyrene microplastics revealed by single-cell transcriptomics profiling
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Microplastics: First Proteomic Analysis on Kidney Tubular Cells
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Scientists exposed human kidney cells to microplastics and BPA (a chemical often found in plastics) and found that these substances changed the levels of several key proteins linked to cell stress, damage, and repair. This is early lab research, not proof of harm in real people yet, but it's one of the first studies to show microplastics may directly disrupt kidney cell function, suggesting we need more research into whether everyday plastic exposure could contribute to kidney disease.
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Researchers orally exposed male Wistar rats to polystyrene microplastics at three doses over four weeks and found dose-dependent disruption of renal energy metabolism, including impaired glycolysis, suppressed gluconeogenesis, and a metabolic shift toward anaerobic pathways, accompanied by progressive histopathological damage including tubular inflammation and loss of Bowman's capsular space.
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Additional file 1 of Single-cell RNA-seq analysis decodes the kidney microenvironment induced by polystyrene microplastics in mice receiving a high-fat diet
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Researchers used single-cell RNA sequencing to decode kidney microenvironmental changes induced by polystyrene microplastics in mice fed a high-fat diet, characterizing mural cell and mesangial cell heterogeneity, DEG profiles, and pathway enrichment in affected renal tissue.
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