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Environmental microplastics (EMPs) exposure alter the differentiation potential of mesenchymal stromal cells

Environmental Research 2022 56 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Hana Najahi, Hana Najahi, Hana Najahi, Hana Najahi, Hana Najahi, Hana Najahi, Hana Najahi, Margherita Ferrante Margherita Ferrante Hana Najahi, Hana Najahi, Margherita Ferrante Gea Oliveri Conti, Hana Najahi, Sergio Minucci, Margherita Ferrante Margherita Ferrante Gea Oliveri Conti, Gea Oliveri Conti, Nicola Alessio, Margherita Ferrante Margherita Ferrante Margherita Ferrante Gea Oliveri Conti, Mohamed Bannı, Gea Oliveri Conti, Gea Oliveri Conti, Gea Oliveri Conti, Gea Oliveri Conti, Gea Oliveri Conti, Sergio Minucci, Gea Oliveri Conti, Gea Oliveri Conti, Margherita Ferrante Nicola Alessio, Nicola Alessio, Nicola Alessio, Imed Messaoudi, Gea Oliveri Conti, Imed Messaoudi, Mohamed Bannı, Imed Messaoudi, Mohamed Bannı, Mohamed Bannı, Tiziana Squillaro, Tiziana Squillaro, Margherita Ferrante Gea Oliveri Conti, Gea Oliveri Conti, Gea Oliveri Conti, Gea Oliveri Conti, Margherita Ferrante Gea Oliveri Conti, Imed Messaoudi, Mohamed Bannı, Sergio Minucci, Sergio Minucci, Gea Oliveri Conti, Gea Oliveri Conti, Gea Oliveri Conti, Margherita Ferrante Margherita Ferrante Margherita Ferrante Margherita Ferrante Sergio Minucci, Margherita Ferrante Hana Najahi, Hana Najahi, Imed Messaoudi, Mohamed Bannı, Margherita Ferrante Margherita Ferrante Hana Najahi, Mohamed Bannı, Mohamed Bannı, Gea Oliveri Conti, Gea Oliveri Conti, Margherita Ferrante Giovanni Di Bernardo, Giovanni Di Bernardo, Giovanni Di Bernardo, Hana Najahi, Mohamed Bannı, Imed Messaoudi, Mohamed Bannı, Imed Messaoudi, Imed Messaoudi, Margherita Ferrante Sergio Minucci, Margherita Ferrante Umberto Galderisi, Umberto Galderisi, Umberto Galderisi, Mohamed Bannı, Mohamed Bannı, Mohamed Bannı, Mohamed Bannı, Mohamed Bannı, Gea Oliveri Conti, Margherita Ferrante Imed Messaoudi, Mohamed Bannı, Gea Oliveri Conti, Margherita Ferrante Gea Oliveri Conti, Imed Messaoudi, Mohamed Bannı, Sergio Minucci, Mohamed Bannı, Mohamed Bannı, Sergio Minucci, Mohamed Bannı, Giovanni Di Bernardo, Mohamed Bannı, Margherita Ferrante Mohamed Bannı, Imed Messaoudi, Mohamed Bannı, Margherita Ferrante Mohamed Bannı, Mohamed Bannı, Imed Messaoudi, Mohamed Bannı, Mohamed Bannı, Umberto Galderisi, Sergio Minucci, Sergio Minucci, Sergio Minucci, Sergio Minucci, Gea Oliveri Conti, Gea Oliveri Conti, Mohamed Bannı, Mohamed Bannı, Mohamed Bannı, Mohamed Bannı, Mohamed Bannı, Mohamed Bannı, Margherita Ferrante Mohamed Bannı, Sergio Minucci, Gea Oliveri Conti, Mohamed Bannı, Gea Oliveri Conti, Sergio Minucci, Margherita Ferrante Margherita Ferrante Mohamed Bannı, Mohamed Bannı, Mohamed Bannı, Margherita Ferrante Mohamed Bannı, Mohamed Bannı, Margherita Ferrante Mohamed Bannı, Mohamed Bannı, Mohamed Bannı, Mohamed Bannı, Margherita Ferrante Mohamed Bannı, Gea Oliveri Conti, Margherita Ferrante

Summary

Researchers evaluated the effects of different-sized microplastics found in water bottles on human bone marrow-derived mesenchymal stromal cells. The study found that microplastic exposure altered the differentiation potential of these cells, suggesting that environmental microplastics could potentially affect tissue renewal and homeostasis.

Polymers

PE PET

Body Systems

Hematopoietic Musculoskeletal

Humans are exposed to environmental microplastic (MPs) that can be frequent in surrounding environment. The mesenchymal stromal cells are a heterogeneous population, which contain fibroblasts and stromal cells, progenitor cells and stem cells. They are part of the stromal component of most tissue and organs in our organisms. Any injury to their functions may impair tissue renewal and homeostasis. We evaluated the effects of different size MPs that could be present in water bottles on human bone marrow mesenchymal stromal cells (BMMSCs) and adipose mesenchymal stromal cells (AMSCs). MPs of polyethylene terephthalate (MPs-PET) (<1 μm and <2.6 μm) were tested in this study. PET treatments induced a reduction in proliferating cells (around 30%) associated either with the onset of senescence or increase in apoptosis. The AMSCs and BMMSCs exposed to PET showed an alteration of differentiation potential. AMSCs remained in an early stage of adipocyte differentiation as shown by high levels of mRNA for Peroxisome Proliferator Activated Receptor Gamma (PPARG) (7.51 vs 1.00) and reduction in Lipoprotein Lipase (LPL) mRNA levels (0.5 vs 1.0). A loss of differentiation capacity was also observed for the osteocyte phenotype in BMMSCs. In particular, we observed a reduction in Bone Gamma-Carboxy glutamate Protein (BGLAP) (0.4 for PET1 and 0.6 for PET2.6 vs 0.1 CTRL) and reduction in Osteopontin (SPP1) (0.3 for PET 1 and 0.64 for PET 2.6 vs 0.1 CTRL). This pioneering mesenchymal cell response study demonstrated that environmental microplastic could be bioavailable for cell uptake and may further lead to irreversible diseases.

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