Uptake, Transport, and Toxicity of Pristine and Weathered Micro- and Nanoplastics in Human Placenta Cells
Environmental Health Perspectives2022
116 citations
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Score: 60
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Hanna M. Dusza,
A. Dick Vethaak
A. Dick Vethaak,
Juliette Legler,
Juliette Legler,
Hanna M. Dusza,
Hanna M. Dusza,
Hanna M. Dusza,
Eugene A. Katrukha,
A. Dick Vethaak,
A. Dick Vethaak,
A. Dick Vethaak,
Sandra M. Nijmeijer,
A. Dick Vethaak,
Sandra M. Nijmeijer,
A. Dick Vethaak
A. Dick Vethaak,
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak
Juliette Legler,
A. Dick Vethaak,
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak,
A. Dick Vethaak,
A. Dick Vethaak,
Sandra M. Nijmeijer,
Juliette Legler,
Sandra M. Nijmeijer,
Hanna M. Dusza,
A. Dick Vethaak,
Juliette Legler,
Juliette Legler,
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak,
A. Dick Vethaak,
A. Dick Vethaak
Sandra M. Nijmeijer,
Sandra M. Nijmeijer,
A. Dick Vethaak
A. Dick Vethaak,
A. Dick Vethaak,
A. Dick Vethaak
A. Dick Vethaak,
A. Dick Vethaak
A. Dick Vethaak
Juliette Legler,
A. Dick Vethaak
A. Dick Vethaak,
A. Dick Vethaak
A. Dick Vethaak,
A. Dick Vethaak,
Anna Akhmanova,
A. Dick Vethaak,
Hanna M. Dusza,
A. Dick Vethaak,
Juliette Legler,
A. Dick Vethaak,
A. Dick Vethaak
A. Dick Vethaak,
A. Dick Vethaak,
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak,
A. Dick Vethaak
A. Dick Vethaak
Juliette Legler,
A. Dick Vethaak,
Douglas I. Walker,
A. Dick Vethaak,
Juliette Legler,
A. Dick Vethaak
Juliette Legler,
Juliette Legler,
A. Dick Vethaak
A. Dick Vethaak,
Juliette Legler,
A. Dick Vethaak,
A. Dick Vethaak,
A. Dick Vethaak,
Hanna M. Dusza,
A. Dick Vethaak,
A. Dick Vethaak,
A. Dick Vethaak,
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak,
A. Dick Vethaak
A. Dick Vethaak,
Hanna M. Dusza,
A. Dick Vethaak
A. Dick Vethaak,
Juliette Legler,
A. Dick Vethaak
Hanna M. Dusza,
A. Dick Vethaak,
Hanna M. Dusza,
A. Dick Vethaak,
A. Dick Vethaak,
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak
A. Dick Vethaak,
Juliette Legler,
A. Dick Vethaak
Douglas I. Walker,
A. Dick Vethaak,
Juliette Legler,
A. Dick Vethaak,
A. Dick Vethaak
Douglas I. Walker,
Douglas I. Walker,
A. Dick Vethaak,
A. Dick Vethaak
Summary
Researchers tested how both new and environmentally weathered micro- and nanoplastics are taken up by human placental cells in laboratory experiments. They found that the placental cells internalized and transported plastic particles regardless of whether they were pristine or aged, with some types affecting gene expression. The study suggests that placental cells are vulnerable to microplastic exposure and that weathering in the environment does not eliminate the particles' ability to enter human tissue.
Our results suggest that pristine and weathered MNPs are internalized and translocated in placental cells <i>in vitro</i>. Effects on gene expression observed upon pristine PS and HDPE particle exposure warrant further examination. More in-depth investigations are needed to better understand the potential health risks of MNP and chemicals associated with them under environmentally relevant exposure scenarios. https://doi.org/10.1289/EHP10873.