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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Nanoplastics Reproductive & Development Sign in to save

Uptake, Transport, and Toxicity of Pristine and Weathered Micro- and Nanoplastics in Human Placenta Cells

Environmental Health Perspectives 2022 116 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Hanna M. Dusza, Eugene A. Katrukha, Sandra M. Nijmeijer, Anna Akhmanova, A. Dick Vethaak, Douglas I. Walker, Juliette Legler

Summary

Researchers tested how both new and environmentally weathered micro- and nanoplastics are taken up by human placental cells in laboratory experiments. They found that the placental cells internalized and transported plastic particles regardless of whether they were pristine or aged, with some types affecting gene expression. The study suggests that placental cells are vulnerable to microplastic exposure and that weathering in the environment does not eliminate the particles' ability to enter human tissue.

Polymers
Body Systems
Study Type In vitro

Our results suggest that pristine and weathered MNPs are internalized and translocated in placental cells in vitro. Effects on gene expression observed upon pristine PS and HDPE particle exposure warrant further examination. More in-depth investigations are needed to better understand the potential health risks of MNP and chemicals associated with them under environmentally relevant exposure scenarios. https://doi.org/10.1289/EHP10873.

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