We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Faculty Opinions recommendation of Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway.
No summary available — this paper's abstract is not included in the open metadata provided by the publisher. Learn why →
More Papers Like This
Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway
AI summary Read the abstract
Mice exposed to polystyrene microplastics in their drinking water for 180 days showed significant reproductive damage, including reduced testosterone, lower sperm quality, and changes in testicular structure. The researchers identified a specific hormonal pathway through which microplastics suppress testosterone production in the cells that make it. This long-term, low-dose study is particularly relevant because the exposure levels are closer to what humans might experience in everyday life.
Reproductive Toxicity of Chronic Exposure To Polystyrene Microplastics And The Molecular Mechanism of Decrease In Testosterone Levels In Male Mice
AI summary Read the abstract
Chronic exposure to polystyrene microplastics lowered testosterone levels in male mice and disrupted reproductive organ function. The study identified molecular pathways through which microplastics interfere with male hormone production, with implications for reproductive health in humans exposed through diet.
The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge
AI summary Read the abstract
Researchers administered polystyrene nanoplastics orally to male rats for five weeks and found significant reductions in testosterone, LH, and FSH levels, sperm DNA damage, altered testicular gene expression, and dose-dependent histological lesions, indicating that nanoplastic exposure disrupts the hormonal axis governing male reproductive function.
Chronic exposure to polystyrene microplastics induced LHR reduction and decreased testosterone levels through NF-κB pathway
AI summary Read the abstract
Mice given drinking water containing polystyrene microplastics for 180 days showed significant drops in testosterone levels through a newly identified mechanism. The microplastics triggered immune cells in the testes to release inflammatory signals that suppressed a key hormone receptor (LHR), disrupting the entire hormonal pathway needed for testosterone production. This finding adds to growing evidence that microplastic exposure may impair male reproductive health.
Unraveling the endocrine disruption potential of microplastics in testosterone regulation
AI summary Read the abstract
Researchers reviewed in vivo evidence that microplastics impair testosterone synthesis through multiple converging mechanisms — oxidative damage to Leydig cells, disruption of the LH/cAMP/StAR steroidogenesis cascade, NF-κB inflammation, and endoplasmic reticulum stress — while flagging a critical gap in human data and the largely unexplored role of physicochemical diversity among plastic types.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.