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Plastic and Placenta: Identification of Polyethylene Glycol (PEG) Compounds in the Human Placenta by HPLC-MS/MS System

International Journal of Molecular Sciences 2022 7 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 40 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Antonio Ragusa, Antonio Ragusa, Antonio Ragusa, Antonio Ragusa, Antonio Ragusa, Antonio Ragusa, Antonio Ragusa, Antonio Ragusa, Antonio Ragusa, Antonio Ragusa, Antonio Ragusa, Antonio Ragusa, Antonio Ragusa, Caterina De Luca, Veronica Lelli, Veronica Lelli, Alessandro Svelato, Alessandro Svelato, Criselda Santacroce, Criselda Santacroce, Alessandro Svelato, Criselda Santacroce, Criselda Santacroce, Giuseppina Fanelli, Alessandro Svelato, Antonio Ragusa, Antonio Ragusa, Piera Catalano, Piera Catalano, Sara D’Avino, Sara D’Avino, Alessandro Svelato, Federica Gevi, Alessandro Svelato, Antonio Ragusa, Antonio Ragusa, Caterina De Luca, Alessandro Svelato, Criselda Santacroce, Criselda Santacroce, Mauro Rongioletti, Sara D’Avino, Caterina De Luca, Caterina De Luca, Mauro Rongioletti, Mauro Rongioletti, Mauro Rongioletti, Sara D’Avino, Piera Catalano, Mauro Rongioletti, Alessandra Gulotta, Sara D’Avino, Sara D’Avino, Mauro Rongioletti, Alessandra Gulotta, Alessandra Gulotta, Caterina De Luca, Mauro Rongioletti, Alessandra Gulotta, Mauro Rongioletti, Alessandra Gulotta, Alessandra Gulotta, Piera Catalano, Sara Rinalducci, Criselda Santacroce, Criselda Santacroce, Anna Maria Timperio

Summary

Researchers detected polyethylene glycol (PEG) compounds — a petroleum-derived polymer used widely in medicine and industry — in human placenta samples for the first time using high-performance liquid chromatography-mass spectrometry, raising questions about fetal exposure to synthetic polymers.

Polymers

Body Systems

Reproductive

The placenta is a crucial interface between the fetus and the maternal environment. It allows for nutrient absorption, thermal regulation, waste elimination, and gas exchange through the mother's blood supply. Furthermore, the placenta determines important adjustments and epigenetic modifications that can change the phenotypic expression of the individual even long after birth. Polyethylene glycol (PEG) is a polyether compound derived from petroleum with many applications, from medicine to industrial manufacturing. In this study, for the first time, an integration of ultra-high-performance liquid chromatography (UHPLC) coupled with mass spectrometry (MS) was used to detect suites of PEG compounds in human placenta samples, collected from 12 placentas, originating from physiological pregnancy. In 10 placentas, we identified fragments of PEG in both chorioamniotic membranes and placental cotyledons, for a total of 36 samples.

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